Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study

Karen C. Schliep, Enrique F. Schisterman, Sunni L. Mumford, Anna Z. Pollack, Cuilin Zhang, Aijun Ye, Joseph B. Stanford, Ahmad O. Hammoud, Christina A. Porucznik, Jean Wactawski-Wende

Research output: Contribution to journalArticle

Abstract

Background: Caffeinated beverages are widely consumed among women of reproductive age, but their association with reproductive hormones, and whether race modifies any such associations, is not well understood. Objective: We assessed the relation between caffeine and caffeinated beverage intake and reproductive hormones in healthy premenopausal women and evaluated the potential effect modification by race. Design: Participants (n = 259) were followed for up to 2 menstrual cycles and provided fasting blood specimens for hormonal assessment at up to 8 visits per cycle and four 24-h dietary recalls per cycle. Weighted linear mixed models and nonlinear mixed models with harmonic terms were used to estimate associations between caffeine and hormone concentrations, adjusted for age, adiposity, physical activity, energy and alcohol intakes, and perceived stress. On the basis of a priori assumptions, an interaction between race and caffeine was tested, and stratified results are presented. Results: Caffeine intake ≥200 mg/d was inversely associated with free estradiol concentrations among white women (β = -0.15; 95% CI: -0.26, -0.05) and positively associated among Asian women (β = 0.61; 95% CI: 0.31, 0.92). Caffeinated soda intake and green tea intake ≥1 cup/d (1 cup = 240 mL) were positively associated with free estradiol concentrations among all races: β = 0.14 (95% CI: 0.06, 0.22) and β = 0.26 (95% CI: 0.07, 0.45), respectively. Conclusions: Moderate consumption of caffeine was associated with reduced estradiol concentrations among white women, whereas caffeinated soda and green tea intakes were associated with increased estradiol concentrations among all races. Further research is warranted on the association between caffeine and caffeinated beverages and reproductive hormones and whether these relations differ by race.

Original languageEnglish (US)
Pages (from-to)488-497
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume95
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

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Beverages
Caffeine
Hormones
Estradiol
Tea
Race Relations
Nonlinear Dynamics
Adiposity
Menstrual Cycle
Energy Intake
Linear Models
Fasting
Alcohols
Exercise
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Schliep, K. C., Schisterman, E. F., Mumford, S. L., Pollack, A. Z., Zhang, C., Ye, A., ... Wactawski-Wende, J. (2012). Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study. American Journal of Clinical Nutrition, 95(2), 488-497. https://doi.org/10.3945/ajcn.111.021287

Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study. / Schliep, Karen C.; Schisterman, Enrique F.; Mumford, Sunni L.; Pollack, Anna Z.; Zhang, Cuilin; Ye, Aijun; Stanford, Joseph B.; Hammoud, Ahmad O.; Porucznik, Christina A.; Wactawski-Wende, Jean.

In: American Journal of Clinical Nutrition, Vol. 95, No. 2, 01.02.2012, p. 488-497.

Research output: Contribution to journalArticle

Schliep, KC, Schisterman, EF, Mumford, SL, Pollack, AZ, Zhang, C, Ye, A, Stanford, JB, Hammoud, AO, Porucznik, CA & Wactawski-Wende, J 2012, 'Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study', American Journal of Clinical Nutrition, vol. 95, no. 2, pp. 488-497. https://doi.org/10.3945/ajcn.111.021287
Schliep, Karen C. ; Schisterman, Enrique F. ; Mumford, Sunni L. ; Pollack, Anna Z. ; Zhang, Cuilin ; Ye, Aijun ; Stanford, Joseph B. ; Hammoud, Ahmad O. ; Porucznik, Christina A. ; Wactawski-Wende, Jean. / Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study. In: American Journal of Clinical Nutrition. 2012 ; Vol. 95, No. 2. pp. 488-497.
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