Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women

Anna Z. Pollack, Enrique F. Schisterman, Lynn R. Goldman, Sunni L. Mumford, Paul S. Albert, Robert L. Jones, Jean Wactawski-Wende

Research output: Contribution to journalArticle

Abstract

Background: Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women. Objectives: We examined the associations between cadmium, lead, and mercury, and anovulation and patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 premenopausal women 18-44 years of age who were enrolled in the BioCycle Study in Buffalo, New York. Methods: Women were followed for up to two menstrual cycles, with serum samples collected up to eight times per cycle. Metal concentrations were determined at baseline in whole blood by inductively coupled mass spectroscopy. Marginal structural models with stabilized inverse probability weights and nonlinear mixed models with harmonic terms were used to estimate the effects of cadmium, lead, and mercury on reproductive hormone levels during the menstrual cycle and anovulation. Results: Geometric mean (interquartile range) cadmium, lead, and mercury levels were 0.29 (0.19-0.43) μg/L, 0.93 (0.68-1.20) μg/dL, and 1.03 (0.58-2.10) μg/L, respectively. We observed decreases in mean FSH with increasing cadmium [second vs. first tertile: -10.0%; 95% confidence interval (CI), -17.3% to -2.5%; third vs. first tertile: -8.3%; 95% CI, -16.0% to 0.1%] and increases in mean progesterone with increasing lead level (second vs. first tertile: 7.5%; 95% CI, 0.1-15.4%; third vs. first tertile: 6.8%; 95% CI, -0.8% to 14.9%). Metals were not significantly associated with anovulation. Conclusions: Our findings support the hypothesis that environmentally relevant levels of metals are associated with modest changes in reproductive hormone levels in healthy, premenopausal women.

Original languageEnglish (US)
Pages (from-to)1156-1161
Number of pages6
JournalEnvironmental Health Perspectives
Volume119
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Anovulation
Mercury
Cadmium
Metals
Hormones
Confidence Intervals
Follicle Stimulating Hormone
Menstrual Cycle
Progesterone
Nonlinear Dynamics
Buffaloes
Structural Models
Luteinizing Hormone
Estradiol
Mass Spectrometry
Weights and Measures
Lead
Serum

Keywords

  • Anovulation
  • Cadmium
  • Lead
  • Menstrual cycle
  • Mercury
  • Reproductive hormones

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Pollack, A. Z., Schisterman, E. F., Goldman, L. R., Mumford, S. L., Albert, P. S., Jones, R. L., & Wactawski-Wende, J. (2011). Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. Environmental Health Perspectives, 119(8), 1156-1161. https://doi.org/10.1289/ehp.1003284

Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. / Pollack, Anna Z.; Schisterman, Enrique F.; Goldman, Lynn R.; Mumford, Sunni L.; Albert, Paul S.; Jones, Robert L.; Wactawski-Wende, Jean.

In: Environmental Health Perspectives, Vol. 119, No. 8, 08.2011, p. 1156-1161.

Research output: Contribution to journalArticle

Pollack, AZ, Schisterman, EF, Goldman, LR, Mumford, SL, Albert, PS, Jones, RL & Wactawski-Wende, J 2011, 'Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women', Environmental Health Perspectives, vol. 119, no. 8, pp. 1156-1161. https://doi.org/10.1289/ehp.1003284
Pollack, Anna Z. ; Schisterman, Enrique F. ; Goldman, Lynn R. ; Mumford, Sunni L. ; Albert, Paul S. ; Jones, Robert L. ; Wactawski-Wende, Jean. / Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. In: Environmental Health Perspectives. 2011 ; Vol. 119, No. 8. pp. 1156-1161.
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abstract = "Background: Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women. Objectives: We examined the associations between cadmium, lead, and mercury, and anovulation and patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 premenopausal women 18-44 years of age who were enrolled in the BioCycle Study in Buffalo, New York. Methods: Women were followed for up to two menstrual cycles, with serum samples collected up to eight times per cycle. Metal concentrations were determined at baseline in whole blood by inductively coupled mass spectroscopy. Marginal structural models with stabilized inverse probability weights and nonlinear mixed models with harmonic terms were used to estimate the effects of cadmium, lead, and mercury on reproductive hormone levels during the menstrual cycle and anovulation. Results: Geometric mean (interquartile range) cadmium, lead, and mercury levels were 0.29 (0.19-0.43) μg/L, 0.93 (0.68-1.20) μg/dL, and 1.03 (0.58-2.10) μg/L, respectively. We observed decreases in mean FSH with increasing cadmium [second vs. first tertile: -10.0{\%}; 95{\%} confidence interval (CI), -17.3{\%} to -2.5{\%}; third vs. first tertile: -8.3{\%}; 95{\%} CI, -16.0{\%} to 0.1{\%}] and increases in mean progesterone with increasing lead level (second vs. first tertile: 7.5{\%}; 95{\%} CI, 0.1-15.4{\%}; third vs. first tertile: 6.8{\%}; 95{\%} CI, -0.8{\%} to 14.9{\%}). Metals were not significantly associated with anovulation. Conclusions: Our findings support the hypothesis that environmentally relevant levels of metals are associated with modest changes in reproductive hormone levels in healthy, premenopausal women.",
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AU - Schisterman, Enrique F.

AU - Goldman, Lynn R.

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AU - Albert, Paul S.

AU - Jones, Robert L.

AU - Wactawski-Wende, Jean

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N2 - Background: Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women. Objectives: We examined the associations between cadmium, lead, and mercury, and anovulation and patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 premenopausal women 18-44 years of age who were enrolled in the BioCycle Study in Buffalo, New York. Methods: Women were followed for up to two menstrual cycles, with serum samples collected up to eight times per cycle. Metal concentrations were determined at baseline in whole blood by inductively coupled mass spectroscopy. Marginal structural models with stabilized inverse probability weights and nonlinear mixed models with harmonic terms were used to estimate the effects of cadmium, lead, and mercury on reproductive hormone levels during the menstrual cycle and anovulation. Results: Geometric mean (interquartile range) cadmium, lead, and mercury levels were 0.29 (0.19-0.43) μg/L, 0.93 (0.68-1.20) μg/dL, and 1.03 (0.58-2.10) μg/L, respectively. We observed decreases in mean FSH with increasing cadmium [second vs. first tertile: -10.0%; 95% confidence interval (CI), -17.3% to -2.5%; third vs. first tertile: -8.3%; 95% CI, -16.0% to 0.1%] and increases in mean progesterone with increasing lead level (second vs. first tertile: 7.5%; 95% CI, 0.1-15.4%; third vs. first tertile: 6.8%; 95% CI, -0.8% to 14.9%). Metals were not significantly associated with anovulation. Conclusions: Our findings support the hypothesis that environmentally relevant levels of metals are associated with modest changes in reproductive hormone levels in healthy, premenopausal women.

AB - Background: Metals can interfere with hormonal functioning by binding at the receptor site and through indirect mechanisms; thus, they may be associated with hormonal changes in premenopausal women. Objectives: We examined the associations between cadmium, lead, and mercury, and anovulation and patterns of reproductive hormones [estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone] among 252 premenopausal women 18-44 years of age who were enrolled in the BioCycle Study in Buffalo, New York. Methods: Women were followed for up to two menstrual cycles, with serum samples collected up to eight times per cycle. Metal concentrations were determined at baseline in whole blood by inductively coupled mass spectroscopy. Marginal structural models with stabilized inverse probability weights and nonlinear mixed models with harmonic terms were used to estimate the effects of cadmium, lead, and mercury on reproductive hormone levels during the menstrual cycle and anovulation. Results: Geometric mean (interquartile range) cadmium, lead, and mercury levels were 0.29 (0.19-0.43) μg/L, 0.93 (0.68-1.20) μg/dL, and 1.03 (0.58-2.10) μg/L, respectively. We observed decreases in mean FSH with increasing cadmium [second vs. first tertile: -10.0%; 95% confidence interval (CI), -17.3% to -2.5%; third vs. first tertile: -8.3%; 95% CI, -16.0% to 0.1%] and increases in mean progesterone with increasing lead level (second vs. first tertile: 7.5%; 95% CI, 0.1-15.4%; third vs. first tertile: 6.8%; 95% CI, -0.8% to 14.9%). Metals were not significantly associated with anovulation. Conclusions: Our findings support the hypothesis that environmentally relevant levels of metals are associated with modest changes in reproductive hormone levels in healthy, premenopausal women.

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