Cadaveric orthotopic auxiliary split liver transplantation and kidney transplantation: An alternative for type 1 primary hyperoxaluria

Nicholas Onaca, Edmund Q. Sanchez, Larry B. Melton, George J. Netto, Karl A. Glastad, Patriciu A. Martin, Takehisa Ueno, Marlon F. Levy, Robert M. Goldstein, Goran B. Klintmalm

Research output: Contribution to journalArticlepeer-review

Abstract

Liver transplantation (LTX) corrects the enzymatic defect responsible for type 1 primary hyperoxaluria (PH1). It has been advocated in combination with kidney transplantation (KTX) in patients with renal failure from PH1 because KTX alone can result in early graft loss. A 58-year-old male patient with PH1 on hemodialysis underwent resection of the left lateral segment of the liver followed by orthotopic auxiliary left lateral segment liver transplantation and kidney transplantation from a deceased donor. The serum oxalate dropped from 34.8 μmol/L before transplant to 3.6-8.3 in the first months posttransplant to < 1 μmol/L (normal range 0.4-3.0). One year after posttransplant, the patient has an iothalamate glomerular filtration rate of 58 ml/min. Orthotopic auxiliary LTX is an alternative to whole LTX in PH1. By using a split deceased donor liver, it does not deprive the donor pool and protects the recipient from liver failure in case of graft loss.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalTransplantation
Volume80
Issue number3
DOIs
StatePublished - Aug 15 2005

Keywords

  • Enzymatic defect
  • Organ allocation

ASJC Scopus subject areas

  • Transplantation

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