Abstract
Liver transplantation (LTX) corrects the enzymatic defect responsible for type 1 primary hyperoxaluria (PH1). It has been advocated in combination with kidney transplantation (KTX) in patients with renal failure from PH1 because KTX alone can result in early graft loss. A 58-year-old male patient with PH1 on hemodialysis underwent resection of the left lateral segment of the liver followed by orthotopic auxiliary left lateral segment liver transplantation and kidney transplantation from a deceased donor. The serum oxalate dropped from 34.8 μmol/L before transplant to 3.6-8.3 in the first months posttransplant to < 1 μmol/L (normal range 0.4-3.0). One year after posttransplant, the patient has an iothalamate glomerular filtration rate of 58 ml/min. Orthotopic auxiliary LTX is an alternative to whole LTX in PH1. By using a split deceased donor liver, it does not deprive the donor pool and protects the recipient from liver failure in case of graft loss.
Original language | English (US) |
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Pages (from-to) | 421-424 |
Number of pages | 4 |
Journal | Transplantation |
Volume | 80 |
Issue number | 3 |
DOIs | |
State | Published - Aug 15 2005 |
Externally published | Yes |
Keywords
- Enzymatic defect
- Organ allocation
ASJC Scopus subject areas
- Transplantation