Ca2+-activated mechanisms in toxicity and programmed cell death

S. Orrenius, David McConkey, D. P. Jones, P. Nicotera

Research output: Contribution to journalArticle

Abstract

Rapid development in the understanding of the role of the calcium ion in signal transduction and regulation of physiological processes has occurred during the last decade because of significant improvements both in analytical approaches and in general understanding of signal transduction mechanisms. Along with this increased knowledge has come the recognition that disturbances in the intracellular Ca2+ homeostasis can be central to a variety of toxicological and pathological processes. We now know of several potential mechanisms whereby changes in intracellular free calcium can activate cytotoxic mechanisms. In this article, we summarize the potential role of these processes in cell killing.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalISI Atlas of Science: Pharmacology
Volume2
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Signal Transduction
Cell Death
Physiological Phenomena
Calcium
Pathologic Processes
Toxicology
Homeostasis
Ions

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ca2+-activated mechanisms in toxicity and programmed cell death. / Orrenius, S.; McConkey, David; Jones, D. P.; Nicotera, P.

In: ISI Atlas of Science: Pharmacology, Vol. 2, No. 4, 1988, p. 319-324.

Research output: Contribution to journalArticle

Orrenius, S, McConkey, D, Jones, DP & Nicotera, P 1988, 'Ca2+-activated mechanisms in toxicity and programmed cell death', ISI Atlas of Science: Pharmacology, vol. 2, no. 4, pp. 319-324.
Orrenius, S. ; McConkey, David ; Jones, D. P. ; Nicotera, P. / Ca2+-activated mechanisms in toxicity and programmed cell death. In: ISI Atlas of Science: Pharmacology. 1988 ; Vol. 2, No. 4. pp. 319-324.
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