C9ORF72 expansion in a family with bipolar disorder

Miriam H. Meisler, Adrienne E. Grant, Julie M. Jones, Guy M. Lenk, Fang He, Peter K. Todd, Masoud Kamali, Roger L. Albin, Andrew P. Lieberman, Scott A. Langenecker, Melvin G. Mcinnis

    Research output: Contribution to journalArticle

    Abstract

    Objective: To investigate the role in bipolar disorder of the C9ORF72 hexanucleotide repeat expansion responsible for frontotemporal lobe dementia and amyotrophic lateral sclerosis. Methods: Eighty-nine subjects from a previously described panel of individuals with bipolar disorder ascertained for genetic studies were screened to detect expansion of the C9ORF72 repeat. One two-generation family with bipolar disorder and an expanded repeat was characterized in depth using molecular diagnostics, imaging, histopathology, and neurological and neuropsychological evaluation. Results: One proband, with the typical clinical presentation of bipolar disorder, carried an expanded C9ORF72 allele of heterogeneous length between 14 and 20 kilobases (kb) as assessed by Southern blot. The expanded allele was inherited from a parent with atypical, late onset clinical features of bipolar disorder, who subsequently progressed to frontotemporal lobe dementia. The expansion in peripheral blood of the parent ranged from 8.5 to 20 kb. Cultured lymphoblastoid cells from this parent exhibited a homogeneous expansion of only 8.5 kb. Conclusions: The disease course in the two generations described here demonstrates that expansion of the C9ORF72 may be associated with a form of bipolar disorder that presents clinically with classic phenomenology and progression to neurodegenerative disease. The frequency in our bipolar disorder cohort was only 1%, indicating that C9ORF72 is not a major contributor to bipolar disorder. DNA from cultured cells may be biased towards shorter repeats and nonrepresentative of the endogenous C9ORF72 expansion.

    Original languageEnglish (US)
    Pages (from-to)326-332
    Number of pages7
    JournalBipolar Disorders
    Volume15
    Issue number3
    DOIs
    StatePublished - May 1 2013

      Fingerprint

    Keywords

    • Atypical bipolar
    • C9ORF72
    • Repeat expansion

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

    Cite this

    Meisler, M. H., Grant, A. E., Jones, J. M., Lenk, G. M., He, F., Todd, P. K., Kamali, M., Albin, R. L., Lieberman, A. P., Langenecker, S. A., & Mcinnis, M. G. (2013). C9ORF72 expansion in a family with bipolar disorder. Bipolar Disorders, 15(3), 326-332. https://doi.org/10.1111/bdi.12063