C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC

Lindsey R. Hayes; Jeffrey D. Rothstein

doi:10.1016/j.neuron.2016.04.026

C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC

Lindsey R. Hayes, Jeffrey D. Rothstein

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (. Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.

Original language	English (US)
Pages (from-to)	427-431
Number of pages	5
Journal	Neuron
Volume	90
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2016.04.026
State	Published - May 4 2016

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2016.04.026

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title = "C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC",

abstract = "For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (. Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.",

author = "Hayes, {Lindsey R.} and Rothstein, {Jeffrey D.}",

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AU - Hayes, Lindsey R.

AU - Rothstein, Jeffrey D.

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Y1 - 2016/5/4

N2 - For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (. Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.

AB - For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories (. Liu et al., 2016; Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.

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C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC

Abstract

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