TY - JOUR
T1 - C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survival
AU - Genkinger, Jeanine M.
AU - Platz, Elizabeth A.
AU - Hoffman, Sandy C.
AU - Strickland, Paul
AU - Huang, Han Yao
AU - Comstock, George W.
AU - Helzlsouer, Kathy J.
N1 - Funding Information:
This study was supported by grants from the National Institute on Aging, #IU01AG18033, National Cancer Institute #IU01CA86308, National Institute of Environmental Health Sciences #P30-ES03819, and Department of Defense #DAMD17-94-J. We acknowledge the contributions of the CLUE data staff Alyce E. Burke, Lucy Thuita and Judy Hoffman-Bolton, and the study participants who donated their time and blood samples to us.
PY - 2006/4
Y1 - 2006/4
N2 - Introduction and objective: Manganese superoxide dismutase (MnSOD), an enzyme that catalyzes superoxide radical quenching, is hypothesized to protect against premature aging. A C47T transition in the MnSOD gene may affect the enzyme's distribution to the mitochondrion, a site of high oxidative stress. We examined the association between this polymorphism and survival. Methods: Individuals who donated a blood sample to the CLUE I and II campaigns in 1974 and 1989, respectively, and completed a food frequency questionnaire in 1989 (N = 6151) were included in the analysis. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models. Mortality follow-up extended from 1989 to 2002. Results: MnSOD genotype distributions were 27% CC (wildtype homozygotes), 50% CT (heterozygotes) and 23% TT (variant homozygotes). TT and CT genotypes compared to the CC genotype were not associated with all-cause or cardiovascular disease mortality. A slight, but non-statistically significant higher risk of cancer mortality was observed for the CT (HR = 1.13, 95% CI: 0.86-1.49) and TT (HR = 1.24, 95% CI: 0.90-1.70) genotypes compared to CC genotype (p-trend = 0.19). Conclusion: We did not observe an association between the C47T polymorphism in the MnSOD gene and survival. These null associations were not modified by fruit and vegetable intake, cigarette smoking status, or body mass index.
AB - Introduction and objective: Manganese superoxide dismutase (MnSOD), an enzyme that catalyzes superoxide radical quenching, is hypothesized to protect against premature aging. A C47T transition in the MnSOD gene may affect the enzyme's distribution to the mitochondrion, a site of high oxidative stress. We examined the association between this polymorphism and survival. Methods: Individuals who donated a blood sample to the CLUE I and II campaigns in 1974 and 1989, respectively, and completed a food frequency questionnaire in 1989 (N = 6151) were included in the analysis. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models. Mortality follow-up extended from 1989 to 2002. Results: MnSOD genotype distributions were 27% CC (wildtype homozygotes), 50% CT (heterozygotes) and 23% TT (variant homozygotes). TT and CT genotypes compared to the CC genotype were not associated with all-cause or cardiovascular disease mortality. A slight, but non-statistically significant higher risk of cancer mortality was observed for the CT (HR = 1.13, 95% CI: 0.86-1.49) and TT (HR = 1.24, 95% CI: 0.90-1.70) genotypes compared to CC genotype (p-trend = 0.19). Conclusion: We did not observe an association between the C47T polymorphism in the MnSOD gene and survival. These null associations were not modified by fruit and vegetable intake, cigarette smoking status, or body mass index.
KW - Disease
KW - Mortality
KW - Oxidation
KW - Polymorphism
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U2 - 10.1016/j.mad.2005.12.006
DO - 10.1016/j.mad.2005.12.006
M3 - Article
C2 - 16458347
AN - SCOPUS:33344470282
SN - 0047-6374
VL - 127
SP - 371
EP - 377
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 4
ER -