C2AB: A molecular glue for lipid vesicles with a negatively charged surface

Jiajie Diao, Tae Young Yoon, Zengliu Su, Yeon Kyun Shin, Taekjip Ha

Research output: Contribution to journalArticle

Abstract

Artificial particulate systems such as lipid vesicles are found in a variety of biomedical applications such as drug delivery and targeting. More versatile layers of control would be added if liposomes could be glued together on demand while stabilized against fusion. Here, we present a two-component molecular glue composed of a protein and calcium ions, with each component specialized for fast and specific binding to negatively charged lipid membranes. Uponmixing the two components, the high affinity binding of this glue starts to tightly bridge two lipid vesicles on a subsecond scale. Furthermore, highly charged liposomes are beneficial in preventing spontaneous fusion before applying the molecular glue.

Original languageEnglish (US)
Pages (from-to)7177-7180
Number of pages4
JournalLangmuir
Volume25
Issue number13
DOIs
StatePublished - Jul 7 2009
Externally publishedYes

Fingerprint

glues
Glues
Lipids
lipids
Liposomes
Fusion reactions
fusion
Membrane Lipids
Drug delivery
particulates
affinity
calcium
Calcium
delivery
drugs
Ions
membranes
proteins
Proteins
ions

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

C2AB : A molecular glue for lipid vesicles with a negatively charged surface. / Diao, Jiajie; Yoon, Tae Young; Su, Zengliu; Shin, Yeon Kyun; Ha, Taekjip.

In: Langmuir, Vol. 25, No. 13, 07.07.2009, p. 7177-7180.

Research output: Contribution to journalArticle

Diao, Jiajie ; Yoon, Tae Young ; Su, Zengliu ; Shin, Yeon Kyun ; Ha, Taekjip. / C2AB : A molecular glue for lipid vesicles with a negatively charged surface. In: Langmuir. 2009 ; Vol. 25, No. 13. pp. 7177-7180.
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