C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight

Mardi S. Byerly, Pia S. Petersen, Santosh Ramamurthy, Marcus M. Seldin, Xia Lei, Elayne Provost, Zhikui Wei, Gabriele V. Ronnett, G. William Wong

Research output: Contribution to journalArticle

Abstract

Background: CTRP4 is a conserved member of the C1q family of secreted proteins with poorly defined function. Results: CTRP4 acts in the hypothalamus to modulate food intake and body weight by regulating the expression of orexigenic neuropeptide expression. Conclusion: CTRP4 plays a role in food intake regulation. Significance: This study establishes the first known in vivo function of CTRP4.

Original languageEnglish (US)
Pages (from-to)4055-4069
Number of pages15
JournalJournal of Biological Chemistry
Volume289
Issue number7
DOIs
StatePublished - Feb 14 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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