C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells

Bruno Douradinha, Sean P. McBurney, Klecia M. Soares de Melo, Amanda P. Smith, Neel K. Krishna, Simon M. Barratt-Boyes, Jared D. Evans, Eduardo J.M. Nascimento, Ernesto T.A. Marques

Research output: Contribution to journalArticlepeer-review

Abstract

Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalVirus Research
Volume179
Issue number1
DOIs
StatePublished - Jan 22 2014

Keywords

  • C1q
  • Classical complement pathway
  • Dengue
  • Dengue fever
  • Dengue hemorrhagic fever
  • Viral persistence

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

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