C-reactive protein levels increase during HIV-1 disease progression in rakai, Uganda, despite the absence of microbial translocation

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Introduction: Microbial translocation has been implicated as a contributing factor to the heightened immune activation observed during HIV-1 disease progression. When examined in a longitudinal study of HIV-1 seroconverters in Rakai, Uganda, microbial translocation was not associated with HIV-1 disease progression. However, the role of general immune activation in HIV disease progression in this population was not fully examined. Methods: Longitudinal serum samples of HIV-1 seroconverters in three HIV-1 disease progression groups [long-term nonprogressors (LTNP), standard progressors (SP), and rapid progressors (RP)] from Rakai, Uganda, were tested for levels of C-reactive protein (CRP), a marker for immune activation. Results: CRP levels significantly increased in the SP group (P < 0.0001) but not in the RP group or the LTNP group. CRP levels during the first year post-HIV seroconversion in the RP group were significantly higher than those observed in the LTNP group (P < 0.05). For the entire population, CRP levels negatively correlated with lipopolysaccharide levels (P < 0.05) and were not associated with endotoxin antibody levels. Conclusions: This study suggests that in this population, increased immune activation is significantly associated with HIV-1 disease progression but not microbial translocation.

Original languageEnglish (US)
Pages (from-to)556-559
Number of pages4
JournalJournal of acquired immune deficiency syndromes
Issue number5
StatePublished - Aug 15 2010



  • Africa
  • HIV disease progression
  • immune activation
  • microbial translocation

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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