C-Reactive protein in spinal fluid of children with meningitis

C. James Corrall, James M. Pepple, E. Richard Moxon, Walter T. Hughes

Research output: Contribution to journalArticlepeer-review


We have evaluated a commercially available latex agglutination system for the detection of C-reactive protein in CSF by a prospective study of 56 patients with CSF pleocytosis. On initial lumbar puncture, C-RP was detected in 100% (24/24) of patients with culture-proven bacterial meningitis, compared to 6% (2/32) of patients in the nonbacterial group (χ2c=44.8, P=<0.0001). C-RP in CSF had a sensitivity of 1.0 and a specificity of 0.94 for detecting culture-positive, bacterial meningitis. It was a more sensitive test for differentiating bacterial from nonbacterial meningitis on initial CSF examination than was the number of CSF leukocytes, the absolute number of CSF polymorphonuclear leukocytes, CSF glucose concentration, CSF protein concentration, or Gram staining of CSF. Detection of C-RP by latex agglutination may prove to be a practical and reliable method for differentiating bacterial from nonbacterial meningitis.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalThe Journal of pediatrics
Issue number3
StatePublished - Sep 1981

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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