TY - JOUR
T1 - C-Reactive protein in spinal fluid of children with meningitis
AU - Corrall, C. James
AU - Pepple, James M.
AU - Moxon, E. Richard
AU - Hughes, Walter T.
N1 - Funding Information:
From the Eudowood Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine: Supported in part by Training Grant No. I 7"32 AI 07195-02, National Institute of Allergy and Infectious Diseases, National institutes of Health; and by the Board of the Hospital for Consumptives of Maryland (Eudowood). Dr. Moxon is a recipient of a Research Career Development Award No. 5 K04 AI 00300-02 (National Institute of Allergy and Infectious Diseases). *Reprint address: Eudowood Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins Hospita:, 600 North Wolfe St., CMSC 1109, Baltimore, MD 21205.
PY - 1981/9
Y1 - 1981/9
N2 - We have evaluated a commercially available latex agglutination system for the detection of C-reactive protein in CSF by a prospective study of 56 patients with CSF pleocytosis. On initial lumbar puncture, C-RP was detected in 100% (24/24) of patients with culture-proven bacterial meningitis, compared to 6% (2/32) of patients in the nonbacterial group (χ2c=44.8, P=<0.0001). C-RP in CSF had a sensitivity of 1.0 and a specificity of 0.94 for detecting culture-positive, bacterial meningitis. It was a more sensitive test for differentiating bacterial from nonbacterial meningitis on initial CSF examination than was the number of CSF leukocytes, the absolute number of CSF polymorphonuclear leukocytes, CSF glucose concentration, CSF protein concentration, or Gram staining of CSF. Detection of C-RP by latex agglutination may prove to be a practical and reliable method for differentiating bacterial from nonbacterial meningitis.
AB - We have evaluated a commercially available latex agglutination system for the detection of C-reactive protein in CSF by a prospective study of 56 patients with CSF pleocytosis. On initial lumbar puncture, C-RP was detected in 100% (24/24) of patients with culture-proven bacterial meningitis, compared to 6% (2/32) of patients in the nonbacterial group (χ2c=44.8, P=<0.0001). C-RP in CSF had a sensitivity of 1.0 and a specificity of 0.94 for detecting culture-positive, bacterial meningitis. It was a more sensitive test for differentiating bacterial from nonbacterial meningitis on initial CSF examination than was the number of CSF leukocytes, the absolute number of CSF polymorphonuclear leukocytes, CSF glucose concentration, CSF protein concentration, or Gram staining of CSF. Detection of C-RP by latex agglutination may prove to be a practical and reliable method for differentiating bacterial from nonbacterial meningitis.
UR - http://www.scopus.com/inward/record.url?scp=0019488418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019488418&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(81)80319-8
DO - 10.1016/S0022-3476(81)80319-8
M3 - Article
C2 - 7264788
AN - SCOPUS:0019488418
SN - 0022-3476
VL - 99
SP - 365
EP - 369
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 3
ER -