C-reactive protein and colorectal adenoma in the CLUE II cohort

Konstantinos K. Tsilidis, Thomas P. Erlinger, Nader Rifai, Sandy Hoffman, Judy Hoffman-Bolton, Kathy J. Helzlsouer, Elizabeth A Platz

Research output: Contribution to journalArticle

Abstract

Objective: Circulating C-reactive protein concentration has been associated with colorectal cancer in some studies. Whether C-reactive protein is associated with earlier steps in the natural history of this cancer has not been published (aside from an abstract). Thus, we evaluated the association between plasma C-reactive protein concentration and development of colorectal adenoma in a nested case-control study. Methods: Colorectal adenoma cases (n = 135) and matched controls (n = 269) who had a negative sigmoidoscopy or colonoscopy were identified between baseline in 1989 and 2000 from among participants in the CLUE II cohort of Washington County, Maryland. Cases were confirmed by medical record review. Controls were matched with cases on age, sex, race, date of blood draw, time since last meal, and type of endoscopy. The odds ratio (OR) of adenoma was estimated from conditional logistic regression models. Results: C-reactive protein concentrations were similar between colorectal adenoma cases and controls (median C-reactive protein, 1.31 vs. 1.38 mg/l; p = 0.13). The OR of colorectal adenoma among those in the highest fourth (>2.95 mg/l) of C-reactive protein concentration compared with the lowest fourth (

Original languageEnglish (US)
Pages (from-to)559-567
Number of pages9
JournalCancer Causes and Control
Volume19
Issue number6
DOIs
StatePublished - Aug 2008

Fingerprint

Adenoma
C-Reactive Protein
Logistic Models
Odds Ratio
Sigmoidoscopy
Colonoscopy
Endoscopy
Medical Records
Meals
Case-Control Studies
Blood Proteins
Colorectal Neoplasms
Neoplasms

Keywords

  • C-reactive protein
  • Colorectal neoplasms
  • Inflammation
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Tsilidis, K. K., Erlinger, T. P., Rifai, N., Hoffman, S., Hoffman-Bolton, J., Helzlsouer, K. J., & Platz, E. A. (2008). C-reactive protein and colorectal adenoma in the CLUE II cohort. Cancer Causes and Control, 19(6), 559-567. https://doi.org/10.1007/s10552-008-9117-x

C-reactive protein and colorectal adenoma in the CLUE II cohort. / Tsilidis, Konstantinos K.; Erlinger, Thomas P.; Rifai, Nader; Hoffman, Sandy; Hoffman-Bolton, Judy; Helzlsouer, Kathy J.; Platz, Elizabeth A.

In: Cancer Causes and Control, Vol. 19, No. 6, 08.2008, p. 559-567.

Research output: Contribution to journalArticle

Tsilidis, KK, Erlinger, TP, Rifai, N, Hoffman, S, Hoffman-Bolton, J, Helzlsouer, KJ & Platz, EA 2008, 'C-reactive protein and colorectal adenoma in the CLUE II cohort', Cancer Causes and Control, vol. 19, no. 6, pp. 559-567. https://doi.org/10.1007/s10552-008-9117-x
Tsilidis KK, Erlinger TP, Rifai N, Hoffman S, Hoffman-Bolton J, Helzlsouer KJ et al. C-reactive protein and colorectal adenoma in the CLUE II cohort. Cancer Causes and Control. 2008 Aug;19(6):559-567. https://doi.org/10.1007/s10552-008-9117-x
Tsilidis, Konstantinos K. ; Erlinger, Thomas P. ; Rifai, Nader ; Hoffman, Sandy ; Hoffman-Bolton, Judy ; Helzlsouer, Kathy J. ; Platz, Elizabeth A. / C-reactive protein and colorectal adenoma in the CLUE II cohort. In: Cancer Causes and Control. 2008 ; Vol. 19, No. 6. pp. 559-567.
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