C-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting sprouty2

Xiaoni Li, Xin Liu, Weiyi Xu, Peng Zhou, Ping Gao, Songshan Jiang, Peter E. Lobie, Tao Zhu

Research output: Contribution to journalArticle

Abstract

Background: The regulation of the miR-23a/24-2/27a cluster is largely unknown. Results: EGF induced c-MYC expression to promote the expression of the miR-23a/24-2/27a cluster, resulting in decreased expression of Sprouty2 and increased activation of p44/42 MAPK to stimulate mammary carcinoma cell invasion and subsequent hepatic metastases. Conclusion: EGF promoted mammary carcinoma cell invasion and hepatic metastasis. Significance: The miR-23a/24-2/27a cluster might be used as a biomarker for breast cancer metastasis.

Original languageEnglish (US)
Pages (from-to)18121-18133
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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