c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p

E. R. Fearon, S. E. Antonarakis, D. A. Meyers, M. A. Levine

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    Abstract

    DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey rat 1 oncogene (c-Ha-ras-1), β-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the β-globin locus (Θ = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (Θ = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-β globin-c-Ha-ras-1-insulin.

    Original languageEnglish (US)
    Pages (from-to)329-337
    Number of pages9
    JournalAmerican Journal of Human Genetics
    Volume36
    Issue number2
    Publication statusPublished - 1984

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    ASJC Scopus subject areas

    • Genetics

    Cite this

    Fearon, E. R., Antonarakis, S. E., Meyers, D. A., & Levine, M. A. (1984). c-Ha-ras-1 oncogene lies between β-globin and insulin loci on human chromosome 11p. American Journal of Human Genetics, 36(2), 329-337.