C-deoxyglucose imaging overestimates myocardial viability in subacute infarction of rats

S. Hasegawa, H. Kusuoka, K. Fukuchi, K. Yutani, K. Maruyama, M. Hori, T. Nishimura

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical studies using F-fluorodeoxyglucose suggest that this tracer may overestimate myocardial viability. This study aimed to elucidate whether 2-deoxyglucose accurately indicates myocardial viability at the early phase of myocardial infarction. Autoradiography with C-deoxyglucose was performed in fasting rats whose left coronary artery was occluded for 60 min and then reperfused. C-deoxyglucose was injected 30 min after the reperfusion (acute; n = 10) or 1 week later (subacute; n = 9). Infarction and risk areas were identified by triphenyl tetrazolium chloride or haematoxylin-eosin staining and methylene blue, respectively. Immuno-histochemical staining using anti-glucose transporter 1 and 4 antibodies was performed. At the acute stage, the uptake of deoxyglucose was consistent with the grade of anti-glucose transporter 4 expression. At the subacute stage, the uptake of deoxyglucose in poorly viable myocardium (543.4±343.7%: normalized with the uptake at the right ventricle) as well as in the viable one (335.2±149.8%) in the risk area was significantly greater than that in the remote area (116.4±94.9%, P<0.01). Anti-glucose transporter 1 was expressed in the poorly viable area where inflammatory cells infiltrated. It is concluded that deoxyglucose uptake by inflammatory cells which express anti-glucose transporter 1 causes overestimation of myocardial viability at subacute stage.

Original languageEnglish (US)
Pages (from-to)209-217
Number of pages9
JournalNuclear medicine communications
Volume23
Issue number3
DOIs
StatePublished - Mar 2002

Keywords

  • FDG
  • Glucose transporter
  • Myocardial infarction
  • Myocardial viability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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