c-Abl tyrosine kinase regulates cardiac growth and development

Zhaozhu Qiua, Yong Cang, Stephen P. Goff

Research output: Contribution to journalArticle

Abstract

The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. Here we show that homozygous Abl mutant embryos and newborns on the C57BL/6J background, but not on other backgrounds, display dramatically enlarged hearts and die perinatally. The heart defects can be largely rescued by cardiomyocyte-specific restoration of the full-length c-Abl protein. The cardiac hyperplasia phenotype is not caused by decreased apoptosis, but rather by abnormally increased cardiomyocyte proliferation during later stages of embryogenesis. Genes involved in cardiac stress and remodeling and cell cycle regulation are also up-regulated in the mutant hearts. These findings reveal an essential role for c-Abl in mammalian heart growth and development.

Original languageEnglish (US)
Pages (from-to)1136-1141
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number3
DOIs
StatePublished - Jan 19 2010
Externally publishedYes

Keywords

  • Abelson
  • Heart development
  • Hyperproliferation

ASJC Scopus subject areas

  • General

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