By hook or by crook: Multifaceted DNA-binding properties of MeCP2

Jaehoon Shin, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

Original languageEnglish (US)
Pages (from-to)940-942
Number of pages3
JournalCell
Volume152
Issue number5
DOIs
StatePublished - Feb 28 2013

Fingerprint

Rett Syndrome
Hooks
Chromatin
AT-Hook Motifs
DNA
Mutation
Methyl CpG Binding Domain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

By hook or by crook : Multifaceted DNA-binding properties of MeCP2. / Shin, Jaehoon; Ming, Guo Li; Song, Hongjun.

In: Cell, Vol. 152, No. 5, 28.02.2013, p. 940-942.

Research output: Contribution to journalArticle

Shin, Jaehoon ; Ming, Guo Li ; Song, Hongjun. / By hook or by crook : Multifaceted DNA-binding properties of MeCP2. In: Cell. 2013 ; Vol. 152, No. 5. pp. 940-942.
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