Abstract
Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.
Original language | English (US) |
---|---|
Pages (from-to) | 940-942 |
Number of pages | 3 |
Journal | Cell |
Volume | 152 |
Issue number | 5 |
DOIs | |
State | Published - Feb 28 2013 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology