Abstract
Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 940-942 |
| Number of pages | 3 |
| Journal | Cell |
| Volume | 152 |
| Issue number | 5 |
| DOIs | |
| State | Published - Feb 28 2013 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Shin, J., Ming, G. L., & Song, H. (2013). By hook or by crook: Multifaceted DNA-binding properties of MeCP2. Cell, 152(5), 940-942. https://doi.org/10.1016/j.cell.2013.02.017