By hook or by crook: Multifaceted DNA-binding properties of MeCP2

Jaehoon Shin; Guo Li Ming; Hongjun Song

doi:10.1016/j.cell.2013.02.017

By hook or by crook: Multifaceted DNA-binding properties of MeCP2

Jaehoon Shin, Guo Li Ming, Hongjun Song

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

Original language	English (US)
Pages (from-to)	940-942
Number of pages	3
Journal	Cell
Volume	152
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2013.02.017
State	Published - Feb 28 2013

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2013.02.017

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title = "By hook or by crook: Multifaceted DNA-binding properties of MeCP2",

abstract = "Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mell{\'e}n et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.",

author = "Jaehoon Shin and Ming, {Guo Li} and Hongjun Song",

year = "2013",

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Y1 - 2013/2/28

N2 - Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

AB - Two new studies reveal novel DNA-binding properties of MeCP2, mutations of which cause Rett syndrome. Baker et al. report critical roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syndrome. Mellén et al. find the methyl-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

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By hook or by crook: Multifaceted DNA-binding properties of MeCP2

Abstract

ASJC Scopus subject areas

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