Burst suppression EEG during hypothermia and rapid rewarming in isoflurane-anesthetized rats

Dandan Zhang, Haiyan Ding, Datian Ye, Xiaofeng Jia, Nitish Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Induced hypothermia is known as an efficient neuroprotectant, while rapid posthypothermic rewarming has harmful effects on neural system and worsens cerebral injury. This study investigated burst suppression (BS) pattern in EEG during moderate hypothermia and rapid rewarming in 9 isofluraneanesthetized rats. Temperature-induced changes were observed in BS features throughout the experiment: maximum BS ratio and burst amplitude, and minimum suppression amplitude appeared at the lowest temperature; BS pattern reappeared after rapid posthypothermic rewarming. In addition, it was observed that respiratory rate changed markedly between normothermia and moderate hypothermia while no significant fluctuation was observed in heart rate during the whole experiment. All these findings may have relevance to establish suitable protocol for therapeutic hypothermia in clinic.

Original languageEnglish (US)
Title of host publication2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
DOIs
StatePublished - Sep 6 2010
Event4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 - Chengdu, China
Duration: Jun 18 2010Jun 20 2010

Publication series

Name2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010

Other

Other4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
CountryChina
CityChengdu
Period6/18/106/20/10

Keywords

  • Burst suppression
  • EEG
  • Hypothermia
  • Rapid rewarming

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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