TY - JOUR
T1 - Burkitt’S Lymphoma In The Mengo Districts Of Uganda
T2 - Epidemiologic Features And Their Relationship To Malaria
AU - Morrow, R. H.
AU - Kisuule, A.
AU - Pike, M. C.
AU - Smith, P. G.
N1 - Funding Information:
1 Received May 5, 1975; revised July 21, 1975; accepted October 3, 1975. 2 Supported in part by Public Health Service contracts PH-43-67-47 and PH-43-67-1343 and grant POI CA17054 from the National Cancer Institute (NCI); by the British Empire Cancer Campaign for Research; and by the International Agency for Research on Cancer. 3 Department of Preventive Medicine, Makerere University Medical School, Kampala, Uganda. 4 Present address: Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Ave., Boston, Mass. 02115. 5 On secondment from the Medical Research Council's Statistical Research Unit, London, England. Present address: Cancer Research Project, Departments of Community Medicine and Pediatrics, University of Southern California School of Medicine, 2025 Zonal Ave., Los Angeles, Calif. 90033. 6 Present address: Department of Epidemiology, Harvard School of Public Health. 7 We thank Professor S. Kyalwazi and Dr. John Ziegler for permission to study their patients; Professors M. S. R. Hutt and D. H. Wright of Makerere University, and Drs. L. B. Thomas and C. Berard of NCI for reviewing the biopsy specimens and postmortem slides; and Dr. Wilson Carswell for obtaining information on the distribution of chloroquine during the study period.
PY - 1976/3
Y1 - 1976/3
N2 - An epidemiologic study of 123 patients residing in the Mengo Districts of Uganda, with onset of symptoms of diagnosed Burkitt’s lymphoma (BL) in the period 1959–68, revealed a substantial decline in incidence of BL during that decade. Other significant findings included differences by ethnic group in age of patient at onset of BL, a change in the proportions of patients by ethnic group over the decade, a lower incidence rate of BL in the counties of higher altitude, and a seasonal pattern of onset. There was no evidence of the time-space clustering previously reported for BL in Uganda. The changing pattern of BL in the Mengo Districts was consistent with the hypothesis that severe malaria infection not only is important in the development of BL but also precipitates onset.
AB - An epidemiologic study of 123 patients residing in the Mengo Districts of Uganda, with onset of symptoms of diagnosed Burkitt’s lymphoma (BL) in the period 1959–68, revealed a substantial decline in incidence of BL during that decade. Other significant findings included differences by ethnic group in age of patient at onset of BL, a change in the proportions of patients by ethnic group over the decade, a lower incidence rate of BL in the counties of higher altitude, and a seasonal pattern of onset. There was no evidence of the time-space clustering previously reported for BL in Uganda. The changing pattern of BL in the Mengo Districts was consistent with the hypothesis that severe malaria infection not only is important in the development of BL but also precipitates onset.
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U2 - 10.1093/jnci/56.3.479
DO - 10.1093/jnci/56.3.479
M3 - Article
C2 - 1255780
AN - SCOPUS:0017251671
VL - 56
SP - 479
EP - 483
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -