TY - JOUR
T1 - Burkitt leukemia limited to the bone marrow has a better prognosis than Burkitt lymphoma with bone marrow involvement in adults
AU - Song, Joo Y.
AU - Venkataraman, Girish
AU - Fedoriw, Yuri
AU - Herrera, Alex F.
AU - Siddiqi, Tanya
AU - Alikhan, Mir B.
AU - Kim, Young S.
AU - Murata-Collins, Joyce
AU - Weisenburger, Dennis D.
AU - Liu, Xueli
AU - Duffield, Amy S.
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016/4/2
Y1 - 2016/4/2
N2 - Burkitt lymphoma patients with bulky disease often have bone marrow involvement. However, leukemic presentation of Burkitt lymphoma in the absence of a mass (pure Burkitt leukemia; PBL) is uncommon. Both PBL and Burkitt lymphoma/leukemia, presenting with a tumor mass and marrow involvement (BLL), are considered stage IV disease, which is associated with a poor prognosis. However, there is limited information on the prognosis in adults with PBL because they have typically been included in cohorts of patients with BLL. This study identified 23 patients, which included 10 PBL and 13 BLL cases. Complex karyotypes (100%) were seen in all BLL cases compared to the PBL group (40%; p = 0.061). Patients with PBL had a significantly better 5-year overall survival of 87.5% vs only 24.3% in the BLL group (p = 0.005). The 5-year overall survival of patients with PBL treated with intensive chemotherapy is superior to those with BLL who are similarly treated.
AB - Burkitt lymphoma patients with bulky disease often have bone marrow involvement. However, leukemic presentation of Burkitt lymphoma in the absence of a mass (pure Burkitt leukemia; PBL) is uncommon. Both PBL and Burkitt lymphoma/leukemia, presenting with a tumor mass and marrow involvement (BLL), are considered stage IV disease, which is associated with a poor prognosis. However, there is limited information on the prognosis in adults with PBL because they have typically been included in cohorts of patients with BLL. This study identified 23 patients, which included 10 PBL and 13 BLL cases. Complex karyotypes (100%) were seen in all BLL cases compared to the PBL group (40%; p = 0.061). Patients with PBL had a significantly better 5-year overall survival of 87.5% vs only 24.3% in the BLL group (p = 0.005). The 5-year overall survival of patients with PBL treated with intensive chemotherapy is superior to those with BLL who are similarly treated.
KW - Pure Burkitt leukemia
KW - lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84961057809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961057809&partnerID=8YFLogxK
U2 - 10.3109/10428194.2015.1085529
DO - 10.3109/10428194.2015.1085529
M3 - Article
C2 - 26450341
AN - SCOPUS:84961057809
SN - 1042-8194
VL - 57
SP - 866
EP - 871
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -