Burden of HPV-positive oropharynx cancers among ever and never smokers in the U.S. population

Anil K. Chaturvedi, Gypsyamber D'Souza, Maura L. Gillison, Hormuzd A. Katki

Research output: Contribution to journalArticle

Abstract

Background HPV-positive oropharynx cancer is frequently characterized as a disease of never-smokers due to higher HPV prevalence in oropharynx tumors among never-smokers than ever-smokers. We sought to estimate the burden (incidence rates and case counts) of HPV-positive oropharynx cancers among never, former, and current smokers in the US population by combining data from several sources. Methods We decomposed the SEER population-level incidence of oropharynx cancers into rates among never-, former-, and current-smokers using a formula based upon rate ratios (RR) for the smoking-oropharynx cancer association (NIH-AARP cohort study) and smoking prevalence in the U.S. population (NHANES 2007/2008). These rates were multiplied by smoking strata-specific HPV prevalence in oropharynx cancer patients (RTOG0129) to estimate incidence of HPV-positive and HPV-negative oropharynx cancers, which were applied to the US population of smokers to calculate annual case counts. Analyses were conducted overall and gender-stratified. Results The incidence of HPV-positive oropharynx cancers was significantly higher among ever versus never-smokers in the US population aged 20+ years during 2007/2008 (RR = 1.81; 95%CI = 1.32–2.47), including significantly higher incidence in current smokers (RR = 2.26; 95%CI = 1.60–3.21) and former smokers (RR = 1.38; 95%CI = 1.02–1.85). Of the estimated 6677 (5418 in men and 1259 in women) annually incident HPV-positive oropharynx cancers in the U.S during 2007/2008, 63.3% arose among ever smokers and 36.7% among never-smokers (p 

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalOral Oncology
Volume60
DOIs
StatePublished - Sep 1 2016

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Oropharyngeal Neoplasms
Population
Incidence
Smoking
Oropharynx
Nutrition Surveys
Information Storage and Retrieval
Cohort Studies

Keywords

  • HPV
  • NHANES
  • Oropharynx cancers
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Burden of HPV-positive oropharynx cancers among ever and never smokers in the U.S. population. / Chaturvedi, Anil K.; D'Souza, Gypsyamber; Gillison, Maura L.; Katki, Hormuzd A.

In: Oral Oncology, Vol. 60, 01.09.2016, p. 61-67.

Research output: Contribution to journalArticle

Chaturvedi, Anil K. ; D'Souza, Gypsyamber ; Gillison, Maura L. ; Katki, Hormuzd A. / Burden of HPV-positive oropharynx cancers among ever and never smokers in the U.S. population. In: Oral Oncology. 2016 ; Vol. 60. pp. 61-67.
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abstract = "Background HPV-positive oropharynx cancer is frequently characterized as a disease of never-smokers due to higher HPV prevalence in oropharynx tumors among never-smokers than ever-smokers. We sought to estimate the burden (incidence rates and case counts) of HPV-positive oropharynx cancers among never, former, and current smokers in the US population by combining data from several sources. Methods We decomposed the SEER population-level incidence of oropharynx cancers into rates among never-, former-, and current-smokers using a formula based upon rate ratios (RR) for the smoking-oropharynx cancer association (NIH-AARP cohort study) and smoking prevalence in the U.S. population (NHANES 2007/2008). These rates were multiplied by smoking strata-specific HPV prevalence in oropharynx cancer patients (RTOG0129) to estimate incidence of HPV-positive and HPV-negative oropharynx cancers, which were applied to the US population of smokers to calculate annual case counts. Analyses were conducted overall and gender-stratified. Results The incidence of HPV-positive oropharynx cancers was significantly higher among ever versus never-smokers in the US population aged 20+ years during 2007/2008 (RR = 1.81; 95{\%}CI = 1.32–2.47), including significantly higher incidence in current smokers (RR = 2.26; 95{\%}CI = 1.60–3.21) and former smokers (RR = 1.38; 95{\%}CI = 1.02–1.85). Of the estimated 6677 (5418 in men and 1259 in women) annually incident HPV-positive oropharynx cancers in the U.S during 2007/2008, 63.3{\%} arose among ever smokers and 36.7{\%} among never-smokers (p ",
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AU - Katki, Hormuzd A.

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N2 - Background HPV-positive oropharynx cancer is frequently characterized as a disease of never-smokers due to higher HPV prevalence in oropharynx tumors among never-smokers than ever-smokers. We sought to estimate the burden (incidence rates and case counts) of HPV-positive oropharynx cancers among never, former, and current smokers in the US population by combining data from several sources. Methods We decomposed the SEER population-level incidence of oropharynx cancers into rates among never-, former-, and current-smokers using a formula based upon rate ratios (RR) for the smoking-oropharynx cancer association (NIH-AARP cohort study) and smoking prevalence in the U.S. population (NHANES 2007/2008). These rates were multiplied by smoking strata-specific HPV prevalence in oropharynx cancer patients (RTOG0129) to estimate incidence of HPV-positive and HPV-negative oropharynx cancers, which were applied to the US population of smokers to calculate annual case counts. Analyses were conducted overall and gender-stratified. Results The incidence of HPV-positive oropharynx cancers was significantly higher among ever versus never-smokers in the US population aged 20+ years during 2007/2008 (RR = 1.81; 95%CI = 1.32–2.47), including significantly higher incidence in current smokers (RR = 2.26; 95%CI = 1.60–3.21) and former smokers (RR = 1.38; 95%CI = 1.02–1.85). Of the estimated 6677 (5418 in men and 1259 in women) annually incident HPV-positive oropharynx cancers in the U.S during 2007/2008, 63.3% arose among ever smokers and 36.7% among never-smokers (p 

AB - Background HPV-positive oropharynx cancer is frequently characterized as a disease of never-smokers due to higher HPV prevalence in oropharynx tumors among never-smokers than ever-smokers. We sought to estimate the burden (incidence rates and case counts) of HPV-positive oropharynx cancers among never, former, and current smokers in the US population by combining data from several sources. Methods We decomposed the SEER population-level incidence of oropharynx cancers into rates among never-, former-, and current-smokers using a formula based upon rate ratios (RR) for the smoking-oropharynx cancer association (NIH-AARP cohort study) and smoking prevalence in the U.S. population (NHANES 2007/2008). These rates were multiplied by smoking strata-specific HPV prevalence in oropharynx cancer patients (RTOG0129) to estimate incidence of HPV-positive and HPV-negative oropharynx cancers, which were applied to the US population of smokers to calculate annual case counts. Analyses were conducted overall and gender-stratified. Results The incidence of HPV-positive oropharynx cancers was significantly higher among ever versus never-smokers in the US population aged 20+ years during 2007/2008 (RR = 1.81; 95%CI = 1.32–2.47), including significantly higher incidence in current smokers (RR = 2.26; 95%CI = 1.60–3.21) and former smokers (RR = 1.38; 95%CI = 1.02–1.85). Of the estimated 6677 (5418 in men and 1259 in women) annually incident HPV-positive oropharynx cancers in the U.S during 2007/2008, 63.3% arose among ever smokers and 36.7% among never-smokers (p 

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KW - NHANES

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KW - Smoking

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