Bullous Pemphigoid and Ulcerative Colitis

A. Razzaque Ahmed, Richard P. Kaplan, David Hardy, Edward Feldman, Henry Pitt

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23 Scopus citations


ABSTRACT: A 21‐year‐old white woman, who had ulcerative colitis for 14 years, developed generalized severe bullous pemphigoid. Following the resection of her colon, her skin showed marked clinical improvement, but this was only temporary. Direct immunofluorescence was performed on the surgical specimen and no antibodies (BMZ) to colonic mucosal cells were evident. Anti‐basement membrane zone antibodies were found on direct and indirect immunofluorescent studies and have persisted. Sera from 15 patients with ulcerative colitis and 11 patients with Crohn's disease, evaluated for the presence of an anti‐basement membrane zone antibody did not contain any demonstrable levels of anti‐BMZ antibodies. The co‐existence of ulcerative colitis and bullous pemphigoid is more likely incidental rather than etiopathologic.

Original languageEnglish (US)
Pages (from-to)594-598
Number of pages5
JournalInternational Journal of Dermatology
Issue number10
StatePublished - Dec 1982
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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