Bulky lymphadenopathy with poor clinical outcome is associated with ATM downregulation in B-cell chronic lymphocytic leukemia patients irrespective of 11q23 deletion

Avadhut D. Joshi, John D. Dickinson, Ganapati V. Hegde, Warren G. Sanger, James O. Armitage, Philip J. Bierman, Robert G. Bociek, Marcel P. Devetten, Julie M. Vose, Shantaram S. Joshi

Research output: Contribution to journalArticle

Abstract

B-cell chronic lymphocytic leukemia (B-CLL) is the most common B-cell leukemia among older populations in Western countries. The clinical course of B-CLL is heterogeneous: in some patients the disease course is indolent, in others it is aggressive. The B-CLL subgroups with chromosome 11q23 deletion have been associated with aggressive disease course involving ATM deletion, extensive bulky lymphadenopathy (BLA), and inferior clinical outcome. Using real-time reverse transcriptase-polymerase chain reaction, we found that ATM was consistently underexpressed in B-CLL patients with BLA, irrespective of 11q23 deletion status. In addition, B-CLL patients who presented with BLA had a significantly shorter time to treatment (2 months) than did patients without BLA (74 months). Moreover, gene expression analysis in B-CLL patients with and without BLA revealed differences in expression for genes involved in apoptosis, cell cycle, and cell adhesion. These results indicate an association between BLA and reduced expression of ATM, suggesting a role for ATM in disease progression in B-CLL.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume172
Issue number2
DOIs
StatePublished - Jan 15 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Joshi, A. D., Dickinson, J. D., Hegde, G. V., Sanger, W. G., Armitage, J. O., Bierman, P. J., Bociek, R. G., Devetten, M. P., Vose, J. M., & Joshi, S. S. (2007). Bulky lymphadenopathy with poor clinical outcome is associated with ATM downregulation in B-cell chronic lymphocytic leukemia patients irrespective of 11q23 deletion. Cancer Genetics and Cytogenetics, 172(2), 120-126. https://doi.org/10.1016/j.cancergencyto.2006.07.010