Adoptive T cell transfer studies in mice and in cancer patients have shown substantial potential, but also major barriers, for successful therapeutic outcomes. A new strategy may overcome some of these barriers. T cells can now be engineered with 'autocostimulation' properties along with chimeric receptors specific for tumor antigens (pages 1440-1449).
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)