Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action

Catherine Willett, Jessica Caverly Rae, Katy O. Goyak, Gary Minsavage, Carl Westmoreland, Melvin Andersen, Mark Avigan, Daniel Duché, Georgina Harris, Thomas Hartung, Hartmut Jaeschke, Andre Kleensang, Brigitte Landesmann, Suzanne Martos, Marilyn Matevia, Colleen Toole, Andrew Rowan, Terry Schultz, Jennifer Seed, John SeniorImran Shah, Kalyanasundaram Subramanian, Mathieu Vinken, Paul Watkins

Research output: Contribution to journalArticle

Abstract

A workshop sponsored by the Human Toxicology Project Consortium (HTPC), 'Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action' brought together experts from a wide range of perspectives to inform the process of pathway development and to advance two prototype pathways initially developed by the European Commission Joint Research Center (JRC): liver-specific fibrosis and steatosis. The first half of the workshop focused on the theory and practice of pathway development; the second on liver disease and the two prototype pathways. Participants agreed pathway development is extremely useful for organizing information and found that focusing the theoretical discussion on a specific AOP is helpful. It is important to include several perspectives during pathway development, including information specialists, pathologists, human health and environmental risk assessors, and chemical and product manufacturers, to ensure the biology is well captured and end use is considered.

Original languageEnglish (US)
Pages (from-to)500-519
Number of pages20
JournalALTEX
Volume31
Issue number4
DOIs
StatePublished - 2014

Keywords

  • Adverse outcome pathways
  • In vitro toxicology
  • Liver toxicity
  • Pathways of toxicity
  • Systems toxicology

ASJC Scopus subject areas

  • Pharmacology
  • Medical Laboratory Technology

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  • Cite this

    Willett, C., Rae, J. C., Goyak, K. O., Minsavage, G., Westmoreland, C., Andersen, M., Avigan, M., Duché, D., Harris, G., Hartung, T., Jaeschke, H., Kleensang, A., Landesmann, B., Martos, S., Matevia, M., Toole, C., Rowan, A., Schultz, T., Seed, J., ... Watkins, P. (2014). Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action. ALTEX, 31(4), 500-519. https://doi.org/10.14573/altex.1401281