Building blocks for computational models of angiogenesis

Feilim Mac Gabhann, Emmannouil D. Karagiannis, Aleksander S. Popel

Research output: Contribution to journalConference articlepeer-review

Abstract

Angiogenesis or neovascularization plays a crucial role in a variety of physiological and pathological conditions including cardiovascular disease and cancer, and in tissue engineering. Angiogenesis is a complex process, where emergent behavior of cells results in the formation of microvascular networks. We have begun a systematic development of computation models, starting with models of growth factor interactions with their receptors on the cell surface and the extracellular matrix, proteolysis of the matrix with matrix metalloproteinases, and the associated cell signaling. We will proceed toward a physiome model of angiogenesis, i.e. a set of models spanning multiple levels of biological organization.

Original languageEnglish (US)
Pages (from-to)739-745
Number of pages7
JournalConference Record - Asilomar Conference on Signals, Systems and Computers
Volume1
StatePublished - Dec 1 2004
EventConference Record of the Thirty-Eighth Asilomar Conference on Signals, Systems and Computers - Pacific Grove, CA, United States
Duration: Nov 7 2004Nov 10 2004

ASJC Scopus subject areas

  • Signal Processing
  • Computer Networks and Communications

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