Building blocks for computational models of angiogenesis

Feilim Mac Gabhann, Emmannouil D. Karagiannis, Aleksander S Popel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Angiogenesis or neovascularization plays a crucial role in a variety of physiological and pathological conditions including cardiovascular disease and cancer, and in tissue engineering. Angiogenesis is a complex process, where emergent behavior of cells results in the formation of microvascular networks. We have begun a systematic development of computation models, starting with models of growth factor interactions with their receptors on the cell surface and the extracellular matrix, proteolysis of the matrix with matrix metalloproteinases, and the associated cell signaling. We will proceed toward a physiome model of angiogenesis, i.e. a set of models spanning multiple levels of biological organization.

Original languageEnglish (US)
Title of host publicationConference Record - Asilomar Conference on Signals, Systems and Computers
EditorsM.B. Matthews
Pages739-745
Number of pages7
Volume1
StatePublished - 2004
EventConference Record of the Thirty-Eighth Asilomar Conference on Signals, Systems and Computers - Pacific Grove, CA, United States
Duration: Nov 7 2004Nov 10 2004

Other

OtherConference Record of the Thirty-Eighth Asilomar Conference on Signals, Systems and Computers
CountryUnited States
CityPacific Grove, CA
Period11/7/0411/10/04

Fingerprint

Proteolysis
Cell signaling
Tissue engineering
Cells
Intercellular Signaling Peptides and Proteins
Metalloproteases

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Mac Gabhann, F., Karagiannis, E. D., & Popel, A. S. (2004). Building blocks for computational models of angiogenesis. In M. B. Matthews (Ed.), Conference Record - Asilomar Conference on Signals, Systems and Computers (Vol. 1, pp. 739-745)

Building blocks for computational models of angiogenesis. / Mac Gabhann, Feilim; Karagiannis, Emmannouil D.; Popel, Aleksander S.

Conference Record - Asilomar Conference on Signals, Systems and Computers. ed. / M.B. Matthews. Vol. 1 2004. p. 739-745.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mac Gabhann, F, Karagiannis, ED & Popel, AS 2004, Building blocks for computational models of angiogenesis. in MB Matthews (ed.), Conference Record - Asilomar Conference on Signals, Systems and Computers. vol. 1, pp. 739-745, Conference Record of the Thirty-Eighth Asilomar Conference on Signals, Systems and Computers, Pacific Grove, CA, United States, 11/7/04.
Mac Gabhann F, Karagiannis ED, Popel AS. Building blocks for computational models of angiogenesis. In Matthews MB, editor, Conference Record - Asilomar Conference on Signals, Systems and Computers. Vol. 1. 2004. p. 739-745
Mac Gabhann, Feilim ; Karagiannis, Emmannouil D. ; Popel, Aleksander S. / Building blocks for computational models of angiogenesis. Conference Record - Asilomar Conference on Signals, Systems and Computers. editor / M.B. Matthews. Vol. 1 2004. pp. 739-745
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