Abstract
Angiogenesis or neovascularization plays a crucial role in a variety of physiological and pathological conditions including cardiovascular disease and cancer, and in tissue engineering. Angiogenesis is a complex process, where emergent behavior of cells results in the formation of microvascular networks. We have begun a systematic development of computation models, starting with models of growth factor interactions with their receptors on the cell surface and the extracellular matrix, proteolysis of the matrix with matrix metalloproteinases, and the associated cell signaling. We will proceed toward a physiome model of angiogenesis, i.e. a set of models spanning multiple levels of biological organization.
Original language | English (US) |
---|---|
Pages (from-to) | 739-745 |
Number of pages | 7 |
Journal | Conference Record - Asilomar Conference on Signals, Systems and Computers |
Volume | 1 |
State | Published - 2004 |
Event | Conference Record of the Thirty-Eighth Asilomar Conference on Signals, Systems and Computers - Pacific Grove, CA, United States Duration: Nov 7 2004 → Nov 10 2004 |
ASJC Scopus subject areas
- Signal Processing
- Computer Networks and Communications