Building a new conceptual framework for receptor heteromers

Sergi Ferré; Ruben Baler; Michel Bouvier; Marc G. Caron; Lakshmi A. Devi; Thierry Durroux; Kjell Fuxe; Susan R. George; Jonathan A. Javitch; Martin J. Lohse; Ken Mackie; Graeme Milligan; Kevin D G Pfleger; Jean Philippe Pin; Nora D. Volkow; Maria Waldhoer; Amina S. Woods; Rafael Franco

doi:10.1038/nchembio0309-131

Building a new conceptual framework for receptor heteromers

Sergi Ferré, Ruben Baler, Michel Bouvier, Marc G. Caron, Lakshmi A. Devi, Thierry Durroux, Kjell Fuxe, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, Ken Mackie, Graeme Milligan, Kevin D G Pfleger, Jean Philippe Pin, Nora D. Volkow, Maria Waldhoer, Amina S. Woods, Rafael Franco

Research output: Contribution to journal › Article › peer-review

292 Scopus citations

Abstract

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

Original language	English (US)
Pages (from-to)	131-134
Number of pages	4
Journal	Nature Chemical Biology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/nchembio0309-131
State	Published - Mar 2009
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Biology

Access to Document

10.1038/nchembio0309-131

Cite this

Ferré, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Durroux, T., Fuxe, K., George, S. R., Javitch, J. A., Lohse, M. J., Mackie, K., Milligan, G., Pfleger, K. D. G., Pin, J. P., Volkow, N. D., Waldhoer, M., Woods, A. S., & Franco, R. (2009). Building a new conceptual framework for receptor heteromers. Nature Chemical Biology, 5(3), 131-134. https://doi.org/10.1038/nchembio0309-131

@article{21a8c852e03d4c2d9c87a9d0f3a757c7,

title = "Building a new conceptual framework for receptor heteromers",

abstract = "Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.",

author = "Sergi Ferr{\'e} and Ruben Baler and Michel Bouvier and Caron, {Marc G.} and Devi, {Lakshmi A.} and Thierry Durroux and Kjell Fuxe and George, {Susan R.} and Javitch, {Jonathan A.} and Lohse, {Martin J.} and Ken Mackie and Graeme Milligan and Pfleger, {Kevin D G} and Pin, {Jean Philippe} and Volkow, {Nora D.} and Maria Waldhoer and Woods, {Amina S.} and Rafael Franco",

year = "2009",

month = mar,

doi = "10.1038/nchembio0309-131",

language = "English (US)",

volume = "5",

pages = "131--134",

journal = "Nature Chemical Biology",

issn = "1552-4450",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Building a new conceptual framework for receptor heteromers

AU - Ferré, Sergi

AU - Baler, Ruben

AU - Bouvier, Michel

AU - Caron, Marc G.

AU - Devi, Lakshmi A.

AU - Durroux, Thierry

AU - Fuxe, Kjell

AU - George, Susan R.

AU - Javitch, Jonathan A.

AU - Lohse, Martin J.

AU - Mackie, Ken

AU - Milligan, Graeme

AU - Pfleger, Kevin D G

AU - Pin, Jean Philippe

AU - Volkow, Nora D.

AU - Waldhoer, Maria

AU - Woods, Amina S.

AU - Franco, Rafael

PY - 2009/3

Y1 - 2009/3

N2 - Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

AB - Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

UR - http://www.scopus.com/inward/record.url?scp=60249098735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60249098735&partnerID=8YFLogxK

U2 - 10.1038/nchembio0309-131

DO - 10.1038/nchembio0309-131

M3 - Article

C2 - 19219011

AN - SCOPUS:60249098735

SN - 1552-4450

VL - 5

SP - 131

EP - 134

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 3

ER -

Building a new conceptual framework for receptor heteromers

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this