Budget impact analysis of pneumococcal conjugate vaccines in Colombia

Jorge Gomez, Luz Elena Moreno, Dagna Constenla, Diana Caceres, Edisson Rodriguez

Research output: Contribution to journalArticlepeer-review


Objective: Pneumococcal diseases including invasive pneumococcal disease (IPD), pneumonia, and acute otitis media (AOM) impose a substantial public health burden. This study performed a budget impact analysis of the use of pneumococcal conjugate vaccines (PCVs) in the National Immunization Program (NIP) in Colombia. Methods: We compared the direct medical cost of the scenario without and with PCV vaccination using either pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) or 13-valent pneumococcal conjugate vaccine (PCV-13) over 5 years (2020–2024) from the health-care system perspective. Vaccine efficacy estimates were obtained from published sources and vaccine prices were taken from the Pan-American Health Organization Revolving Fund. Vaccine coverage was assumed to be 90% based on Colombia data. Results: Using PHiD-CV in the NIP in Colombia would reduce the estimated cost for treating pneumococcal disease by US$46.1 m over the 2020–2024 period (US$40.2 m using PCV-13), with a budget impact of US$100.1 m for PHiD-CV (US$121.4 m for PCV-13), and would cost US$3.1 m less per year on vaccine doses than using PCV-13. Conclusion: These findings are potentially valuable for the selection of vaccines for their national immunization programs under conditions of budgetary constraint.

Original languageEnglish (US)
Pages (from-to)255-263
Number of pages9
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Issue number2
StatePublished - 2021
Externally publishedYes


  • 13-valent pneumococcal conjugate vaccine
  • Budget impact analysis
  • colombia
  • pneumococcal conjugate vaccination
  • pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology (medical)


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