B0-orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T

Manisha Aggarwal, Yusuke Kageyama, Xu Li, Peter C. van Zijl

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate B0-field-orientation dependent white matter contrast in the human brainstem based on R2* and frequency difference (Δf) mapping from gradient echo (GRE) imaging at 11.7T. Methods: Multi-echo GRE data were acquired from two fixed human brainstem specimens at multiple orientations with respect to the static B0 field. The B0-orientation dependent modulation curves of R2* and Δf measurements between short and long echo time regimes were used to reconstruct maps of three-dimensional (3D) white matter orientation vectors. The results were compared with maps from diffusion MRI, susceptibility tensor imaging, and histological staining of the same specimens. Results: R2* and Δf maps demonstrated distinct and significant contrast modulation between the corticospinal tract (CST) and transverse pontine fibers (TPF) dependent on B0 orientation. Interleaved fiber orientations of the CST and TPF could be sensitively resolved based on field-orientation-dependent fitting of the R2* and Δf measurements. The fitted 3D orientation vector maps and peak-to-peak amplitude of R2* and Δf modulation exhibited close correspondence to primary eigenvector and anisotropy maps derived from diffusion MRI. The amplitude of B0-orientation dependent R2* modulation was significantly (P <0.005) higher in the CST compared with TPF, while fractional anisotropies were comparable. Conclusion: The findings of this study demonstrate the potential of B0-orientation dependent susceptibility-induced R2* and Δf contrasts to probe tract-specific orientation and microstructure in white matter.

LanguageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - 2016

Fingerprint

Pyramidal Tracts
Brain Stem
Diffusion Magnetic Resonance Imaging
Anisotropy
Staining and Labeling
White Matter

Keywords

  • Anisotropy
  • Frequency difference
  • Magnetic susceptibility
  • Microstructure
  • R
  • White matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "B0-orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T",
abstract = "Purpose: To investigate B0-field-orientation dependent white matter contrast in the human brainstem based on R2* and frequency difference (Δf) mapping from gradient echo (GRE) imaging at 11.7T. Methods: Multi-echo GRE data were acquired from two fixed human brainstem specimens at multiple orientations with respect to the static B0 field. The B0-orientation dependent modulation curves of R2* and Δf measurements between short and long echo time regimes were used to reconstruct maps of three-dimensional (3D) white matter orientation vectors. The results were compared with maps from diffusion MRI, susceptibility tensor imaging, and histological staining of the same specimens. Results: R2* and Δf maps demonstrated distinct and significant contrast modulation between the corticospinal tract (CST) and transverse pontine fibers (TPF) dependent on B0 orientation. Interleaved fiber orientations of the CST and TPF could be sensitively resolved based on field-orientation-dependent fitting of the R2* and Δf measurements. The fitted 3D orientation vector maps and peak-to-peak amplitude of R2* and Δf modulation exhibited close correspondence to primary eigenvector and anisotropy maps derived from diffusion MRI. The amplitude of B0-orientation dependent R2* modulation was significantly (P <0.005) higher in the CST compared with TPF, while fractional anisotropies were comparable. Conclusion: The findings of this study demonstrate the potential of B0-orientation dependent susceptibility-induced R2* and Δf contrasts to probe tract-specific orientation and microstructure in white matter.",
keywords = "Anisotropy, Frequency difference, Magnetic susceptibility, Microstructure, R, White matter",
author = "Manisha Aggarwal and Yusuke Kageyama and Xu Li and {van Zijl}, {Peter C.}",
year = "2016",
doi = "10.1002/mrm.26208",
language = "English (US)",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
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AU - Aggarwal,Manisha

AU - Kageyama,Yusuke

AU - Li,Xu

AU - van Zijl,Peter C.

PY - 2016

Y1 - 2016

N2 - Purpose: To investigate B0-field-orientation dependent white matter contrast in the human brainstem based on R2* and frequency difference (Δf) mapping from gradient echo (GRE) imaging at 11.7T. Methods: Multi-echo GRE data were acquired from two fixed human brainstem specimens at multiple orientations with respect to the static B0 field. The B0-orientation dependent modulation curves of R2* and Δf measurements between short and long echo time regimes were used to reconstruct maps of three-dimensional (3D) white matter orientation vectors. The results were compared with maps from diffusion MRI, susceptibility tensor imaging, and histological staining of the same specimens. Results: R2* and Δf maps demonstrated distinct and significant contrast modulation between the corticospinal tract (CST) and transverse pontine fibers (TPF) dependent on B0 orientation. Interleaved fiber orientations of the CST and TPF could be sensitively resolved based on field-orientation-dependent fitting of the R2* and Δf measurements. The fitted 3D orientation vector maps and peak-to-peak amplitude of R2* and Δf modulation exhibited close correspondence to primary eigenvector and anisotropy maps derived from diffusion MRI. The amplitude of B0-orientation dependent R2* modulation was significantly (P <0.005) higher in the CST compared with TPF, while fractional anisotropies were comparable. Conclusion: The findings of this study demonstrate the potential of B0-orientation dependent susceptibility-induced R2* and Δf contrasts to probe tract-specific orientation and microstructure in white matter.

AB - Purpose: To investigate B0-field-orientation dependent white matter contrast in the human brainstem based on R2* and frequency difference (Δf) mapping from gradient echo (GRE) imaging at 11.7T. Methods: Multi-echo GRE data were acquired from two fixed human brainstem specimens at multiple orientations with respect to the static B0 field. The B0-orientation dependent modulation curves of R2* and Δf measurements between short and long echo time regimes were used to reconstruct maps of three-dimensional (3D) white matter orientation vectors. The results were compared with maps from diffusion MRI, susceptibility tensor imaging, and histological staining of the same specimens. Results: R2* and Δf maps demonstrated distinct and significant contrast modulation between the corticospinal tract (CST) and transverse pontine fibers (TPF) dependent on B0 orientation. Interleaved fiber orientations of the CST and TPF could be sensitively resolved based on field-orientation-dependent fitting of the R2* and Δf measurements. The fitted 3D orientation vector maps and peak-to-peak amplitude of R2* and Δf modulation exhibited close correspondence to primary eigenvector and anisotropy maps derived from diffusion MRI. The amplitude of B0-orientation dependent R2* modulation was significantly (P <0.005) higher in the CST compared with TPF, while fractional anisotropies were comparable. Conclusion: The findings of this study demonstrate the potential of B0-orientation dependent susceptibility-induced R2* and Δf contrasts to probe tract-specific orientation and microstructure in white matter.

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