TY - JOUR
T1 - Brucellosis serology in HIV-infected patients
AU - Abdollahi, Alireza
AU - Morteza, Afsaneh
AU - Khalilzadeh, Omid
AU - Rasoulinejad, Mehrnaz
PY - 2010/10
Y1 - 2010/10
N2 - Background: An accelerated evolution of HIV to AIDS has been reported with brucellosis co-infection. The seroprevalence of brucellosis co-infection with HIV has not been investigated in a brucellosis endemic country like Iran. Methods: We performed a cross-sectional survey of brucellosis serology in HIV-infected patients attending a university hospital, as well as in healthy controls. A total of 90 HIV-positive patients and 100 healthy age-matched controls were recruited. The clinical characteristics, hemoglobin, and red blood cell, platelet, white blood cell, and CD4+ T cell counts were evaluated. Results: Positive brucellosis serology was significantly higher in HIV-infected patients than in controls (73.3% vs. 30%, respectively, odds ratio 6.42, p< 0.001). It was also higher in males than females, p= 0.001. Brucellosis-infected patients had significantly lower hemoglobin and white blood cell counts compared with brucellosis-uninfected patients (p< 0.001). In HIV-positive patients, white blood cell count was significantly lower in brucellosis-infected than brucellosis-uninfected patients (p< 0.05). Conclusions: Our findings show that brucellosis infection is an important infection in HIV-infected patients. The treatment of brucellosis may be of great clinical importance in the management of HIV infection in a brucellosis endemic country like Iran.
AB - Background: An accelerated evolution of HIV to AIDS has been reported with brucellosis co-infection. The seroprevalence of brucellosis co-infection with HIV has not been investigated in a brucellosis endemic country like Iran. Methods: We performed a cross-sectional survey of brucellosis serology in HIV-infected patients attending a university hospital, as well as in healthy controls. A total of 90 HIV-positive patients and 100 healthy age-matched controls were recruited. The clinical characteristics, hemoglobin, and red blood cell, platelet, white blood cell, and CD4+ T cell counts were evaluated. Results: Positive brucellosis serology was significantly higher in HIV-infected patients than in controls (73.3% vs. 30%, respectively, odds ratio 6.42, p< 0.001). It was also higher in males than females, p= 0.001. Brucellosis-infected patients had significantly lower hemoglobin and white blood cell counts compared with brucellosis-uninfected patients (p< 0.001). In HIV-positive patients, white blood cell count was significantly lower in brucellosis-infected than brucellosis-uninfected patients (p< 0.05). Conclusions: Our findings show that brucellosis infection is an important infection in HIV-infected patients. The treatment of brucellosis may be of great clinical importance in the management of HIV infection in a brucellosis endemic country like Iran.
KW - Brucellosis
KW - HIV
KW - Serology
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U2 - 10.1016/j.ijid.2010.04.007
DO - 10.1016/j.ijid.2010.04.007
M3 - Article
C2 - 20705498
AN - SCOPUS:77957750167
VL - 14
SP - e904-e906
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
IS - 10
ER -