Broviac catheter sepsis: The natural history of an iatrogenic infection

Denis R. King, Michael Komer, Janette Hoffman, Margaret E. Ginn-Pease, Mark E. Stanley, Dwight Powell, Richard P. Harmel

Research output: Contribution to journalArticle

Abstract

Between January 1982 and December 1983, 335 Broviac catheters placed in 270 infants and children were prospectively evaluated. The average duration of catheter life was 99.7 days, yielding a total accumulated experience of 33,394 catheter days. Blood culture-proven bacteremia occurred on 77 occasions (23%), an average of one spetic episode for every 434 days of catheter use. Temperature elevation was the only consistent clinical sign of infection occurring in 91% of the children. White blood cell counts remained within the normal range in the majority of patients. The differential counts were most helpful, however, documenting a significant increase in the number of immature neutrophils. The rise in band forms was frequently observed 24 to 48 hours before the onset of clinically evident sepsis. Platelet counts did not change significantly. Eighty-eight microorganisms were identified on blood culture. Eighty-three bacterial isolates were recovered (94%) and five fungi. The vast majority of patients (86%) had a single organism on blood culture but polymicrobial sepsis was observed on 11 occasions. Staphylococcus sp (38%) and Streptococcus sp (25%) species were most common. Of particular importance 48% of coagulase negative staphylococci were nafcillin-resistant. Of the gram negative bacteria, Klebsiella (10%) and Pseudomonas (6%) species were most frequent. In 53 patients, antibiotic therapy was administered in an attempt to salvage the catheter. Bacteremia was controlled successfully in 39 (74%), and in the other 14 children, persistent sepsis dictated catheter removal. One patients (0.4%) died as a result of catheter-related sepsis.

Original languageEnglish (US)
Pages (from-to)728-733
Number of pages6
JournalJournal of Pediatric Surgery
Volume20
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Sepsis
Catheters
Infection
Bacteremia
Staphylococcus
Nafcillin
Klebsiella
Coagulase
Pseudomonas
Streptococcus
Gram-Negative Bacteria
Platelet Count
Leukocyte Count
Reference Values
Neutrophils
Fungi
Anti-Bacterial Agents
Temperature
Blood Culture

Keywords

  • Catheter sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

King, D. R., Komer, M., Hoffman, J., Ginn-Pease, M. E., Stanley, M. E., Powell, D., & Harmel, R. P. (1985). Broviac catheter sepsis: The natural history of an iatrogenic infection. Journal of Pediatric Surgery, 20(6), 728-733. https://doi.org/10.1016/S0022-3468(85)80034-8

Broviac catheter sepsis : The natural history of an iatrogenic infection. / King, Denis R.; Komer, Michael; Hoffman, Janette; Ginn-Pease, Margaret E.; Stanley, Mark E.; Powell, Dwight; Harmel, Richard P.

In: Journal of Pediatric Surgery, Vol. 20, No. 6, 1985, p. 728-733.

Research output: Contribution to journalArticle

King, DR, Komer, M, Hoffman, J, Ginn-Pease, ME, Stanley, ME, Powell, D & Harmel, RP 1985, 'Broviac catheter sepsis: The natural history of an iatrogenic infection', Journal of Pediatric Surgery, vol. 20, no. 6, pp. 728-733. https://doi.org/10.1016/S0022-3468(85)80034-8
King DR, Komer M, Hoffman J, Ginn-Pease ME, Stanley ME, Powell D et al. Broviac catheter sepsis: The natural history of an iatrogenic infection. Journal of Pediatric Surgery. 1985;20(6):728-733. https://doi.org/10.1016/S0022-3468(85)80034-8
King, Denis R. ; Komer, Michael ; Hoffman, Janette ; Ginn-Pease, Margaret E. ; Stanley, Mark E. ; Powell, Dwight ; Harmel, Richard P. / Broviac catheter sepsis : The natural history of an iatrogenic infection. In: Journal of Pediatric Surgery. 1985 ; Vol. 20, No. 6. pp. 728-733.
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