TY - JOUR
T1 - Bronchoscopic intratumoural therapies for non-small cell lung cancer
AU - Demaio, Andrew
AU - Sterman, Daniel
N1 - Publisher Copyright:
© ERS 2020.
PY - 2020/6/30
Y1 - 2020/6/30
N2 - The past decade has brought remarkable improvements in the treatment of non-small cell lung cancer (NSCLC) with novel therapies, such as immune checkpoint inhibitors, although response rates remain suboptimal. Direct intratumoural injection of therapeutic agents via bronchoscopic approaches poses the unique ability to directly target the tumour microenvironment and offers several theoretical advantages over systemic delivery including decreased toxicity. Increases in understanding of the tumour microenvironment and cancer immunology have identified many potential options for intratumoural therapy, especially combination immunotherapies. Herein, we review advances in the development of novel bronchoscopic treatments for NSCLC over the past decade with a focus on the potential of intratumoural immunotherapy alone or in combination with systemic treatments.
AB - The past decade has brought remarkable improvements in the treatment of non-small cell lung cancer (NSCLC) with novel therapies, such as immune checkpoint inhibitors, although response rates remain suboptimal. Direct intratumoural injection of therapeutic agents via bronchoscopic approaches poses the unique ability to directly target the tumour microenvironment and offers several theoretical advantages over systemic delivery including decreased toxicity. Increases in understanding of the tumour microenvironment and cancer immunology have identified many potential options for intratumoural therapy, especially combination immunotherapies. Herein, we review advances in the development of novel bronchoscopic treatments for NSCLC over the past decade with a focus on the potential of intratumoural immunotherapy alone or in combination with systemic treatments.
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U2 - 10.1183/16000617.0028-2020
DO - 10.1183/16000617.0028-2020
M3 - Article
C2 - 32554757
AN - SCOPUS:85086654045
SN - 0905-9180
VL - 29
SP - 1
EP - 14
JO - European Respiratory Review
JF - European Respiratory Review
IS - 156
M1 - 200028
ER -