Bronchodilator pretreatment improves aerosol deposition uniformity in HIV- positive patients who cough while inhaling aerosolized pentamidine

Research output: Contribution to journalArticle

Abstract

Objective: To determine the effect of bronchodilator pretreatment on deposition uniformity of aerosolized pentamidine (AP) in HIV-positive patients who coughed while inhaling AP. Design: Nonrandomized control trial. Setting: A university hospital. Patients: Ten HIV-positive patients who were using AP prophylactically. Intervention: Four patients who coughed during AP administration were pretreated with 10 mg metaproterenol aerosol prior to a second inhalation of AP. Measurements: Skew, a measure of overall deposition symmetry, deposition in the apex vs the base of the right lung (A:B ratio), and percentage of change from baseline in peak expiratory flow rate (PEFR). Results: At baseline, the average (±SD) skew value for four subjects who coughed (0.89 ± 0.19) was significantly higher than for six control subjects (0.58 ± 0.07) (p

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalChest
Volume106
Issue number2
StatePublished - 1994

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Pentamidine
Bronchodilator Agents
Aerosols
Cough
Inhalation
HIV
Metaproterenol
Peak Expiratory Flow Rate
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Bronchodilator pretreatment improves aerosol deposition uniformity in HIV- positive patients who cough while inhaling aerosolized pentamidine",
abstract = "Objective: To determine the effect of bronchodilator pretreatment on deposition uniformity of aerosolized pentamidine (AP) in HIV-positive patients who coughed while inhaling AP. Design: Nonrandomized control trial. Setting: A university hospital. Patients: Ten HIV-positive patients who were using AP prophylactically. Intervention: Four patients who coughed during AP administration were pretreated with 10 mg metaproterenol aerosol prior to a second inhalation of AP. Measurements: Skew, a measure of overall deposition symmetry, deposition in the apex vs the base of the right lung (A:B ratio), and percentage of change from baseline in peak expiratory flow rate (PEFR). Results: At baseline, the average (±SD) skew value for four subjects who coughed (0.89 ± 0.19) was significantly higher than for six control subjects (0.58 ± 0.07) (p",
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year = "1994",
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issn = "0012-3692",
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AU - Harrison, Katharine Santos

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N2 - Objective: To determine the effect of bronchodilator pretreatment on deposition uniformity of aerosolized pentamidine (AP) in HIV-positive patients who coughed while inhaling AP. Design: Nonrandomized control trial. Setting: A university hospital. Patients: Ten HIV-positive patients who were using AP prophylactically. Intervention: Four patients who coughed during AP administration were pretreated with 10 mg metaproterenol aerosol prior to a second inhalation of AP. Measurements: Skew, a measure of overall deposition symmetry, deposition in the apex vs the base of the right lung (A:B ratio), and percentage of change from baseline in peak expiratory flow rate (PEFR). Results: At baseline, the average (±SD) skew value for four subjects who coughed (0.89 ± 0.19) was significantly higher than for six control subjects (0.58 ± 0.07) (p

AB - Objective: To determine the effect of bronchodilator pretreatment on deposition uniformity of aerosolized pentamidine (AP) in HIV-positive patients who coughed while inhaling AP. Design: Nonrandomized control trial. Setting: A university hospital. Patients: Ten HIV-positive patients who were using AP prophylactically. Intervention: Four patients who coughed during AP administration were pretreated with 10 mg metaproterenol aerosol prior to a second inhalation of AP. Measurements: Skew, a measure of overall deposition symmetry, deposition in the apex vs the base of the right lung (A:B ratio), and percentage of change from baseline in peak expiratory flow rate (PEFR). Results: At baseline, the average (±SD) skew value for four subjects who coughed (0.89 ± 0.19) was significantly higher than for six control subjects (0.58 ± 0.07) (p

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