Bronchiolitis in Tropical South India

Thomas Cherian, Eric A F Simoes, Mark C. Steinhoff, K. Chitra, Mercy John, P. Raghupathy, T. Jacob John

Research output: Contribution to journalArticle

Abstract

In a prospective hospital-based study of 328 children under 5 years of age with acute lower respiratory infections, 114 (35%) were diagnosed to have acute bronchiolitis. Of them, 87 (76%) were less than 1 year and 107 (94%) were less than 2 years of age. Signs of severe lower respiratory infections, namely tachypnea (respiratory rate greater than 50/min) and subcostal retraction, were present in 95% and 93%, respectively. Of 88 children of whom roentgenographs were taken, 30 (34%) had evidence of pneumonia. No clinical signs discriminated between those with and without pneumonia. By culture or immunofluorescence antigen detection, viruses were found in 81 (71%) children with bronchiolitis; respiratory syncytial virus was the most common agent, found in 65 (57%). Parainfluenza viruses were the next most common, found in 12 (11%). Most cases of bronchiolitis occurred in outbreaks during the rainy months of August through November, coinciding with respiratory syncytial virus outbreaks. Although bacterial culture of blood was done in 56 children, no respiratory pathogen was isolated. In one child with bronchiolitis and consolidation, postmortem lung aspirate yielded Staphylococcus aureus. Thus, bronchiolitis is primarily a viral syndrome in this tropical region, just as it is in temperate regions. Eight (7%) children died (all were infants); 5 had roentgenographic pneumonia and the remaining had other abnormalities contributing to death; all had been treated with antibiotics. Since one third of lower respiratory infections are bronchiolitis, and among infants under 1 year of age bronchiolitis comprises 47% of all lower respiratory infection cases, criteria for antibiotic management must take into account the availability of roentgenographic investigation.

Original languageEnglish (US)
Pages (from-to)1026-1030
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume144
Issue number9
DOIs
StatePublished - 1990

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Bronchiolitis
India
Respiratory Tract Infections
Pneumonia
Respiratory Syncytial Viruses
Disease Outbreaks
Anti-Bacterial Agents
Viruses
Tachypnea
Paramyxoviridae Infections
Respiratory Rate
Fluorescent Antibody Technique
Staphylococcus aureus
Antigens
Lung

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cherian, T., Simoes, E. A. F., Steinhoff, M. C., Chitra, K., John, M., Raghupathy, P., & John, T. J. (1990). Bronchiolitis in Tropical South India. American Journal of Diseases of Children, 144(9), 1026-1030. https://doi.org/10.1001/archpedi.1990.02150330086028

Bronchiolitis in Tropical South India. / Cherian, Thomas; Simoes, Eric A F; Steinhoff, Mark C.; Chitra, K.; John, Mercy; Raghupathy, P.; John, T. Jacob.

In: American Journal of Diseases of Children, Vol. 144, No. 9, 1990, p. 1026-1030.

Research output: Contribution to journalArticle

Cherian, T, Simoes, EAF, Steinhoff, MC, Chitra, K, John, M, Raghupathy, P & John, TJ 1990, 'Bronchiolitis in Tropical South India', American Journal of Diseases of Children, vol. 144, no. 9, pp. 1026-1030. https://doi.org/10.1001/archpedi.1990.02150330086028
Cherian T, Simoes EAF, Steinhoff MC, Chitra K, John M, Raghupathy P et al. Bronchiolitis in Tropical South India. American Journal of Diseases of Children. 1990;144(9):1026-1030. https://doi.org/10.1001/archpedi.1990.02150330086028
Cherian, Thomas ; Simoes, Eric A F ; Steinhoff, Mark C. ; Chitra, K. ; John, Mercy ; Raghupathy, P. ; John, T. Jacob. / Bronchiolitis in Tropical South India. In: American Journal of Diseases of Children. 1990 ; Vol. 144, No. 9. pp. 1026-1030.
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