Bronchial circulatory reversal of methacholine-induced airway constriction

Research output: Contribution to journalArticle

Abstract

Although a role for the bronchial circulation in clearance of bronchoactive agents has been frequently proposed, experimental evidence is limited. In this study, we determined the importance of bronchial blood flow (Q̇(BA)) in the recovery from methacholine-(MCh) induced bronchoconstriction. In 10 pentobarbital-anesthetized ventilated sheep, the bronchial branch of the bronchoesophageal artery was cannulated and perfused (0.7 ml·min-1·kg-1) with blood pumped from the femoral artery. MCh was infused directly into the bronchial artery at increasing concentrations (10-7 to 10-5 M). MCh infusion caused a concentration-dependent increase in airway resistance at constant Q̇(BA). However, the time constant of recovery (TC) from airway constriction after cessation of the MCh infusion was not dependent on the MCh concentration or the magnitude of the increases in airway resistance. When Q̇(BA) was at 50, 100, and 200% of control level, with constant MCh concentration, TC was 44 ± 6, 25 ± 2, and 24 ± 2 (SE) s at each flow level, respectively. TC at 50% of control Q̇(BA) was significantly greater than at control Q̇(BA) (P <0.01). Thus the magnitude of Q̇(BA) can alter the time course of recovery from MCh-induced increases in airway resistance. These results document the importance of Q̇(BA) in reversing agonist-induced constriction and suggest that an impaired bronchial circulation may contribute to the mechanism of airway hyperreactivity.

Original languageEnglish (US)
Pages (from-to)1220-1224
Number of pages5
JournalJournal of Applied Physiology
Volume69
Issue number4
StatePublished - 1990

Fingerprint

Methacholine Chloride
Constriction
Airway Resistance
Bronchial Arteries
Bronchoconstriction
Pentobarbital
Femoral Artery
Sheep
Arteries

Keywords

  • airway hyperreactivity
  • airway resistance
  • bronchial artery
  • sheep

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Bronchial circulatory reversal of methacholine-induced airway constriction. / Wagner, Elizabeth Marie; Mitzner, Wayne A.

In: Journal of Applied Physiology, Vol. 69, No. 4, 1990, p. 1220-1224.

Research output: Contribution to journalArticle

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