Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons

Eugene R. DeSombre, Paul V. Harper, Alun Hughes, S. John Gatley, Jeffrey L. Schwartz, Onofre T. DeJesus, Ronnie C. Mease

Research output: Contribution to journalArticle

Abstract

While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a key component we studied the 4.4-h half-life, Auger electron-emitting nuclide bromine-80m. When incorporated into DNA this nuclide was radiotoxic to cells in culture and caused substantial chromosomal damage, while similar concentrations of bromine-80m as bromide, or bromoantipyrine were without effect. The mean lethal dose for bromine-80m was 45 atoms per nucleus which is consistent with use in receptor-positive cancers with limited numbers of ER.

Original languageEnglish (US)
Pages (from-to)5805-5809
Number of pages5
JournalCancer Research
Volume48
Issue number20
StatePublished - Oct 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    DeSombre, E. R., Harper, P. V., Hughes, A., Gatley, S. J., Schwartz, J. L., DeJesus, O. T., & Mease, R. C. (1988). Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons. Cancer Research, 48(20), 5805-5809.