Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons

Eugene R. DeSombre; Paul V. Harper; Alun Hughes; S. John Gatley; Jeffrey L. Schwartz; Onofre T. DeJesus; Ronnie C. Mease

Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons

Eugene R. DeSombre, Paul V. Harper, Alun Hughes, S. John Gatley, Jeffrey L. Schwartz, Onofre T. DeJesus, Ronnie C. Mease

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a key component we studied the 4.4-h half-life, Auger electron-emitting nuclide bromine-80m. When incorporated into DNA this nuclide was radiotoxic to cells in culture and caused substantial chromosomal damage, while similar concentrations of bromine-80m as bromide, or bromoantipyrine were without effect. The mean lethal dose for bromine-80m was 45 atoms per nucleus which is consistent with use in receptor-positive cancers with limited numbers of ER.

Original language	English (US)
Pages (from-to)	5805-5809
Number of pages	5
Journal	Cancer Research
Volume	48
Issue number	20
State	Published - Oct 1988
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons",

abstract = "While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a key component we studied the 4.4-h half-life, Auger electron-emitting nuclide bromine-80m. When incorporated into DNA this nuclide was radiotoxic to cells in culture and caused substantial chromosomal damage, while similar concentrations of bromine-80m as bromide, or bromoantipyrine were without effect. The mean lethal dose for bromine-80m was 45 atoms per nucleus which is consistent with use in receptor-positive cancers with limited numbers of ER.",

author = "DeSombre, {Eugene R.} and Harper, {Paul V.} and Alun Hughes and Gatley, {S. John} and Schwartz, {Jeffrey L.} and DeJesus, {Onofre T.} and Mease, {Ronnie C.}",

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T1 - Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons

AU - DeSombre, Eugene R.

AU - Harper, Paul V.

AU - Hughes, Alun

AU - Gatley, S. John

AU - Schwartz, Jeffrey L.

AU - DeJesus, Onofre T.

AU - Mease, Ronnie C.

PY - 1988/10

Y1 - 1988/10

N2 - While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a key component we studied the 4.4-h half-life, Auger electron-emitting nuclide bromine-80m. When incorporated into DNA this nuclide was radiotoxic to cells in culture and caused substantial chromosomal damage, while similar concentrations of bromine-80m as bromide, or bromoantipyrine were without effect. The mean lethal dose for bromine-80m was 45 atoms per nucleus which is consistent with use in receptor-positive cancers with limited numbers of ER.

AB - While theoretically feasible, estrogen receptor (ER)-directed radiotherapy of hormone-dependent cancers has not been realized because no ER-seeking ligand with an appropriate radiotoxic potential has been identified. Since an appropriate nuclide is a key component we studied the 4.4-h half-life, Auger electron-emitting nuclide bromine-80m. When incorporated into DNA this nuclide was radiotoxic to cells in culture and caused substantial chromosomal damage, while similar concentrations of bromine-80m as bromide, or bromoantipyrine were without effect. The mean lethal dose for bromine-80m was 45 atoms per nucleus which is consistent with use in receptor-positive cancers with limited numbers of ER.

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Bromine-80m radiotoxicity and the potential for estrogen receptor-directed therapy with auger electrons

Abstract

ASJC Scopus subject areas

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