Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies

Yan Li, Kazuki Fukushima, Daniel J. Coady, Amanda C. Engler, Shaoqiong Liu, Yuan Huang, John S. Cho, Yi Guo, Lloyd S. Miller, Jeremy P.K. Tan, Pui Lai Rachel Ee, Weimin Fan, Yi Yan Yang, James L. Hedrick

Research output: Contribution to journalArticlepeer-review

Abstract

Fighting the resistance: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad-spectrum antimicrobial activities and biofilm-disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug-resistant infections.

Original languageEnglish (US)
Pages (from-to)674-678
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number2
DOIs
StatePublished - Jan 7 2013
Externally publishedYes

Keywords

  • biofilms
  • electron microscopy
  • gels
  • noncovalent interactions
  • supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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