Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies

Yan Li; Kazuki Fukushima; Daniel J. Coady; Amanda C. Engler; Shaoqiong Liu; Yuan Huang; John S. Cho; Yi Guo; Lloyd S. Miller; Jeremy P.K. Tan; Pui Lai Rachel Ee; Weimin Fan; Yi Yan Yang; James L. Hedrick

doi:10.1002/anie.201206053

Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies

Yan Li, Kazuki Fukushima, Daniel J. Coady, Amanda C. Engler, Shaoqiong Liu, Yuan Huang, John S. Cho, Yi Guo, Lloyd S. Miller, Jeremy P.K. Tan, Pui Lai Rachel Ee, Weimin Fan, Yi Yan Yang, James L. Hedrick

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Fighting the resistance: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad-spectrum antimicrobial activities and biofilm-disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug-resistant infections.

Original language	English (US)
Pages (from-to)	674-678
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	2
DOIs	https://doi.org/10.1002/anie.201206053
State	Published - Jan 7 2013
Externally published	Yes

Keywords

biofilms
electron microscopy
gels
noncovalent interactions
supramolecular chemistry

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201206053

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Li, Y., Fukushima, K., Coady, D. J., Engler, A. C., Liu, S., Huang, Y., Cho, J. S., Guo, Y., Miller, L. S., Tan, J. P. K., Ee, P. L. R., Fan, W., Yang, Y. Y., & Hedrick, J. L. (2013). Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies. Angewandte Chemie - International Edition, 52(2), 674-678. https://doi.org/10.1002/anie.201206053

Li, Y, Fukushima, K, Coady, DJ, Engler, AC, Liu, S, Huang, Y, Cho, JS, Guo, Y, Miller, LS, Tan, JPK, Ee, PLR, Fan, W, Yang, YY & Hedrick, JL 2013, 'Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies', Angewandte Chemie - International Edition, vol. 52, no. 2, pp. 674-678. https://doi.org/10.1002/anie.201206053

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abstract = "Fighting the resistance: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad-spectrum antimicrobial activities and biofilm-disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug-resistant infections.",

keywords = "biofilms, electron microscopy, gels, noncovalent interactions, supramolecular chemistry",

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doi = "10.1002/anie.201206053",

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AU - Liu, Shaoqiong

AU - Huang, Yuan

AU - Cho, John S.

AU - Guo, Yi

AU - Miller, Lloyd S.

AU - Tan, Jeremy P.K.

AU - Ee, Pui Lai Rachel

AU - Fan, Weimin

AU - Yang, Yi Yan

AU - Hedrick, James L.

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KW - electron microscopy

KW - gels

KW - noncovalent interactions

KW - supramolecular chemistry

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Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies

Abstract

Keywords

ASJC Scopus subject areas

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