Brimonidine tartrate: A one-month dose response study

R. J. Derick, Alan L. Robin, T. R. Walters, H. S. Barnebey, N. Choplin, J. Schuman, E. P. Kelley, K. Chen, J. F. Stoecker

Research output: Contribution to journalArticle

Abstract

Background: Brimonidine tartrate is a relatively selective alpha2- agonist that effectively reduces mean intraocular pressure (IOP) and the incidence of IOP spikes after laser trabeculoplasty. The authors were interested in evaluating the dose response of brimonidine when applied topically for a longer duration in patients with elevated IOPs. Methods: The authors conducted a 1-month, multicentered, double-masked, randomized, placebo-controlled, parallel clinical study in 194 patients with ocular hypertension or glaucoma (mean IOP, 25.6 ± 3.2 mmHg). The authors administered three concentrations of brimonidine (0.08%, 0.2%, and 0.5%) or placebo bilaterally every 12 hours for 1 month. The authors evaluated the following parameters: IOP, heart rate, blood pressure, visual acuity, pupil size, basal tear secretion as well as patient comfort at baseline, day 1, week 1, week 3, and week 4. Results: All concentrations of brimonidine significantly reduced IOP, compared to baseline and placebo, at all follow- up visits. Maximum mean IOP decreases from baseline of 20.8%, 27.2%, and 30.1% were observed for the 0.08%, 0.20%, and 0.5% treatment groups, respectively. On days 1 and 21, the 0.2% and 0.5% treatment groups exhibited significantly greater IOP decreases than did the 0.08% group. After the initial steep decline in IOP, the effect decreased slightly and stabilized at day 14 at the level that was maintained throughout the study. The most frequent side effects reported were fatigue and dry mouth. No significant changes in heart rate were reported. Statistically significant decreases in mean blood pressure without clinical symptoms were observed within the 0.2% and 0.5% treatment groups. Conclusion: Brimonidine 0.2% is well tolerated, efficacious, and shows potential as an agent in the long-term treatment of elevated IOP.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalOphthalmology
Volume104
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Intraocular Pressure
Placebos
Heart Rate
Blood Pressure
Brimonidine Tartrate
Ocular Hypertension
Trabeculectomy
Therapeutics
Pupil
Tears
Glaucoma
Visual Acuity
Fatigue
Mouth
Lasers
Incidence

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Derick, R. J., Robin, A. L., Walters, T. R., Barnebey, H. S., Choplin, N., Schuman, J., ... Stoecker, J. F. (1997). Brimonidine tartrate: A one-month dose response study. Ophthalmology, 104(1), 131-136.

Brimonidine tartrate : A one-month dose response study. / Derick, R. J.; Robin, Alan L.; Walters, T. R.; Barnebey, H. S.; Choplin, N.; Schuman, J.; Kelley, E. P.; Chen, K.; Stoecker, J. F.

In: Ophthalmology, Vol. 104, No. 1, 1997, p. 131-136.

Research output: Contribution to journalArticle

Derick, RJ, Robin, AL, Walters, TR, Barnebey, HS, Choplin, N, Schuman, J, Kelley, EP, Chen, K & Stoecker, JF 1997, 'Brimonidine tartrate: A one-month dose response study', Ophthalmology, vol. 104, no. 1, pp. 131-136.
Derick RJ, Robin AL, Walters TR, Barnebey HS, Choplin N, Schuman J et al. Brimonidine tartrate: A one-month dose response study. Ophthalmology. 1997;104(1):131-136.
Derick, R. J. ; Robin, Alan L. ; Walters, T. R. ; Barnebey, H. S. ; Choplin, N. ; Schuman, J. ; Kelley, E. P. ; Chen, K. ; Stoecker, J. F. / Brimonidine tartrate : A one-month dose response study. In: Ophthalmology. 1997 ; Vol. 104, No. 1. pp. 131-136.
@article{2275efcb81044eae9cba041b2631138e,
title = "Brimonidine tartrate: A one-month dose response study",
abstract = "Background: Brimonidine tartrate is a relatively selective alpha2- agonist that effectively reduces mean intraocular pressure (IOP) and the incidence of IOP spikes after laser trabeculoplasty. The authors were interested in evaluating the dose response of brimonidine when applied topically for a longer duration in patients with elevated IOPs. Methods: The authors conducted a 1-month, multicentered, double-masked, randomized, placebo-controlled, parallel clinical study in 194 patients with ocular hypertension or glaucoma (mean IOP, 25.6 ± 3.2 mmHg). The authors administered three concentrations of brimonidine (0.08{\%}, 0.2{\%}, and 0.5{\%}) or placebo bilaterally every 12 hours for 1 month. The authors evaluated the following parameters: IOP, heart rate, blood pressure, visual acuity, pupil size, basal tear secretion as well as patient comfort at baseline, day 1, week 1, week 3, and week 4. Results: All concentrations of brimonidine significantly reduced IOP, compared to baseline and placebo, at all follow- up visits. Maximum mean IOP decreases from baseline of 20.8{\%}, 27.2{\%}, and 30.1{\%} were observed for the 0.08{\%}, 0.20{\%}, and 0.5{\%} treatment groups, respectively. On days 1 and 21, the 0.2{\%} and 0.5{\%} treatment groups exhibited significantly greater IOP decreases than did the 0.08{\%} group. After the initial steep decline in IOP, the effect decreased slightly and stabilized at day 14 at the level that was maintained throughout the study. The most frequent side effects reported were fatigue and dry mouth. No significant changes in heart rate were reported. Statistically significant decreases in mean blood pressure without clinical symptoms were observed within the 0.2{\%} and 0.5{\%} treatment groups. Conclusion: Brimonidine 0.2{\%} is well tolerated, efficacious, and shows potential as an agent in the long-term treatment of elevated IOP.",
author = "Derick, {R. J.} and Robin, {Alan L.} and Walters, {T. R.} and Barnebey, {H. S.} and N. Choplin and J. Schuman and Kelley, {E. P.} and K. Chen and Stoecker, {J. F.}",
year = "1997",
language = "English (US)",
volume = "104",
pages = "131--136",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Brimonidine tartrate

T2 - A one-month dose response study

AU - Derick, R. J.

AU - Robin, Alan L.

AU - Walters, T. R.

AU - Barnebey, H. S.

AU - Choplin, N.

AU - Schuman, J.

AU - Kelley, E. P.

AU - Chen, K.

AU - Stoecker, J. F.

PY - 1997

Y1 - 1997

N2 - Background: Brimonidine tartrate is a relatively selective alpha2- agonist that effectively reduces mean intraocular pressure (IOP) and the incidence of IOP spikes after laser trabeculoplasty. The authors were interested in evaluating the dose response of brimonidine when applied topically for a longer duration in patients with elevated IOPs. Methods: The authors conducted a 1-month, multicentered, double-masked, randomized, placebo-controlled, parallel clinical study in 194 patients with ocular hypertension or glaucoma (mean IOP, 25.6 ± 3.2 mmHg). The authors administered three concentrations of brimonidine (0.08%, 0.2%, and 0.5%) or placebo bilaterally every 12 hours for 1 month. The authors evaluated the following parameters: IOP, heart rate, blood pressure, visual acuity, pupil size, basal tear secretion as well as patient comfort at baseline, day 1, week 1, week 3, and week 4. Results: All concentrations of brimonidine significantly reduced IOP, compared to baseline and placebo, at all follow- up visits. Maximum mean IOP decreases from baseline of 20.8%, 27.2%, and 30.1% were observed for the 0.08%, 0.20%, and 0.5% treatment groups, respectively. On days 1 and 21, the 0.2% and 0.5% treatment groups exhibited significantly greater IOP decreases than did the 0.08% group. After the initial steep decline in IOP, the effect decreased slightly and stabilized at day 14 at the level that was maintained throughout the study. The most frequent side effects reported were fatigue and dry mouth. No significant changes in heart rate were reported. Statistically significant decreases in mean blood pressure without clinical symptoms were observed within the 0.2% and 0.5% treatment groups. Conclusion: Brimonidine 0.2% is well tolerated, efficacious, and shows potential as an agent in the long-term treatment of elevated IOP.

AB - Background: Brimonidine tartrate is a relatively selective alpha2- agonist that effectively reduces mean intraocular pressure (IOP) and the incidence of IOP spikes after laser trabeculoplasty. The authors were interested in evaluating the dose response of brimonidine when applied topically for a longer duration in patients with elevated IOPs. Methods: The authors conducted a 1-month, multicentered, double-masked, randomized, placebo-controlled, parallel clinical study in 194 patients with ocular hypertension or glaucoma (mean IOP, 25.6 ± 3.2 mmHg). The authors administered three concentrations of brimonidine (0.08%, 0.2%, and 0.5%) or placebo bilaterally every 12 hours for 1 month. The authors evaluated the following parameters: IOP, heart rate, blood pressure, visual acuity, pupil size, basal tear secretion as well as patient comfort at baseline, day 1, week 1, week 3, and week 4. Results: All concentrations of brimonidine significantly reduced IOP, compared to baseline and placebo, at all follow- up visits. Maximum mean IOP decreases from baseline of 20.8%, 27.2%, and 30.1% were observed for the 0.08%, 0.20%, and 0.5% treatment groups, respectively. On days 1 and 21, the 0.2% and 0.5% treatment groups exhibited significantly greater IOP decreases than did the 0.08% group. After the initial steep decline in IOP, the effect decreased slightly and stabilized at day 14 at the level that was maintained throughout the study. The most frequent side effects reported were fatigue and dry mouth. No significant changes in heart rate were reported. Statistically significant decreases in mean blood pressure without clinical symptoms were observed within the 0.2% and 0.5% treatment groups. Conclusion: Brimonidine 0.2% is well tolerated, efficacious, and shows potential as an agent in the long-term treatment of elevated IOP.

UR - http://www.scopus.com/inward/record.url?scp=0031056490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031056490&partnerID=8YFLogxK

M3 - Article

C2 - 9022117

AN - SCOPUS:0031056490

VL - 104

SP - 131

EP - 136

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 1

ER -