Abstract
Background: Mycobacterium tuberculosis (TB) infection induces systemic inflammation that could impact HIV-1 persistence. Setting: HIV-1-seropositive individuals either with or without pulmonary TB disease were recruited in Kampala, Uganda. Methods: Plasma cytokines, HIV-1 DNA, and cell-associated (ca)- RNA were compared among those coinfected with TB (cases) to those without TB (controls). TB-coinfected cases and controls were compared at presentation (n = 15 and n = 16, respectively) and at around 6 months after HIV-1 treatment initiation among those who had achieved virologic suppression (n = 6 and n = 8, respectively). At follow-up, the TB-coinfected cases had also finished TB treatment. Results: Before treatment, the TB-coinfected cases as compared to the controls had higher levels of soluble(s)-CD163 (P = 0.0002) and interleukin-6 (P = 0.006) but lower levels of macrophage chemoattractant protein-1 (P = 0.04). After treatment, the TB-coinfected cases as compared to controls still had higher plasma s-CD163 levels (P = 0007). Controls as compared to the coinfected cases had higher ca-RNA per DNA template both at baseline (P = 0.03) and at followup (P = 0.07). Levels of ca-RNA per DNA copy at follow-up showed a negative correlation with baseline plasma s-CD163 (P = 0.008) and interleukin-6 (P = 0.05) levels. Conclusions: TB disease is associated with inflammation and decreased HIV-1 RNA expression relative to the number of infected cells, both before and after viral suppression. Infections present before antiretroviral initiation impact HIV-1 latency.
Original language | English (US) |
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Pages (from-to) | 407-411 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 79 |
Issue number | 3 |
DOIs | |
State | Published - 2018 |
Keywords
- Cell-associated HIV RNA
- HIV-1 latency
- Inflammation
- Tuberculosis
- Viral transcription
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)