TY - JOUR
T1 - Brief report
T2 - No association between premorbid adjustment in adult-onset schizophrenia and genetic variation in dysbindin
AU - Schirmbeck, Frederike
AU - Georgi, Alexander
AU - Strohmaier, Jana
AU - Schmael, Christine
AU - Boesshenz, Katja V.
AU - Mühleisen, Thomas W.
AU - Herms, Stefan
AU - Hoffmann, Per
AU - Jamra, Rami Abou
AU - Schumacher, Johannes
AU - Maier, Wolfgang
AU - Propping, Peter
AU - Nöthen, Markus M.
AU - Cichon, Sven
AU - Rietschel, Marcella
AU - Schulze, Thomas G.
PY - 2008/11
Y1 - 2008/11
N2 - Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.
AB - Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.
KW - Complex genetics
KW - Endophenotype
KW - Haplotypes
KW - Phenotype dissection
KW - Premorbid functioning
KW - Susceptibility genes
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U2 - 10.1007/s10803-008-0582-6
DO - 10.1007/s10803-008-0582-6
M3 - Article
C2 - 18473158
AN - SCOPUS:56349141502
SN - 0162-3257
VL - 38
SP - 1977
EP - 1981
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 10
ER -