Brief report: No association between premorbid adjustment in adult-onset schizophrenia and genetic variation in dysbindin

Frederike Schirmbeck, Alexander Georgi, Jana Strohmaier, Christine Schmael, Katja V. Boesshenz, Thomas W. Mühleisen, Stefan Herms, Per Hoffmann, Rami Abou Jamra, Johannes Schumacher, Wolfgang Maier, Peter Propping, Markus M. Nöthen, Sven Cichon, Marcella Rietschel, Thomas G. Schulze

Research output: Contribution to journalArticlepeer-review

Abstract

Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.

Original languageEnglish (US)
Pages (from-to)1977-1981
Number of pages5
JournalJournal of Autism and Developmental Disorders
Volume38
Issue number10
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Complex genetics
  • Endophenotype
  • Haplotypes
  • Phenotype dissection
  • Premorbid functioning
  • Susceptibility genes

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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