Brief Report: Medication Sharing is Rare among African HIV-1 Serodiscordant Couples Enrolled in an Efficacy Trial of Oral Pre-exposure Prophylaxis (PrEP) for HIV-1 Prevention

Kerry A. Thomson, Jessica E. Haberer, Mark A. Marzinke, Andrew Mujugira, Craig W. Hendrix, Connie Celum, Patrick Ndase, Allan Ronald, David R. Bangsberg, Jared M. Baeten

Research output: Contribution to journalArticle

Abstract

Sharing of pre-exposure prophylaxis (PrEP) medications is a concern for PrEP implementation. For HIV-1 serodiscordant couples, sharing may undermine the HIV-1 prevention benefit and also cause antiretroviral resistance if taken by HIV-1 infected partners. Within a PrEP efficacy trial among HIV-1 serodiscordant couples, we assessed the occurrence of PrEP sharing by self-report and plasma tenofovir concentrations in HIV-1 infected partners. PrEP sharing was self-reported at <0.01% of visits, and 0%-1.6% of randomly selected and 0% of purposively selected specimens from HIV-1 infected participants had detectable tenofovir concentrations (median: 66.5 ng/mL, range: 1.3-292 ng/mL). PrEP sharing within HIV-1 serodiscordant couples was extremely rare.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalJournal of acquired immune deficiency syndromes
Volume75
Issue number2
DOIs
StatePublished - Jun 1 2017

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Keywords

  • HIV-1
  • HIV-1 serodiscordant couples
  • adherence
  • pre-exposure prophylaxis
  • prescription drug diversion

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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