Brief Report: Impact of ART on Maternal Health After Cessation of Breastfeeding

Sean S. Brummel; Taha E. Taha; Konstantia Angelidou; Friday Saidi; Patience Atuhaire; Dingase Dula; Dhayendre Moodley; Allen Matubu; Gift Chareka; Neetal Nevrekar; Tichaona Vhembo; Lee Fairlie; Gerhard Theron; Pendo Mlay; Kathleen George; Michael Basar; Nahida Chakhtoura; Renee Browning; Mary Glenn Fowler; Judith S. Currier

doi:10.1097/QAI.0000000000002586

Brief Report: Impact of ART on Maternal Health After Cessation of Breastfeeding

Sean S. Brummel, Taha E. Taha, Konstantia Angelidou, Friday Saidi, Patience Atuhaire, Dingase Dula, Dhayendre Moodley, Allen Matubu, Gift Chareka, Neetal Nevrekar, Tichaona Vhembo, Lee Fairlie, Gerhard Theron, Pendo Mlay, Kathleen George, Michael Basar, Nahida Chakhtoura, Renee Browning, Mary Glenn Fowler, Judith S. Currier

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract:IMPAACT PROMISE 1077BF/FF was a sequentially randomized study of pregnant and postpartum women living with HIV to investigate the efficacy and safety of antiretroviral therapy (ART). This Maternal Health Component investigated efficacy for the risk of developing AIDS or death; and safety among women randomized to continue ART (CTART: N = 289) or discontinue ART (N = 268) after cessation of breastfeeding or after confirmation of infant infection. No AIDS-defining illnesses were reported during follow-up in either arm. Adverse events of grade 3 or higher were more frequent in the CTART arm [hazard ratio = 1.78, 95% confidence interval: (1.05 to 3.02), P-value = 0.03]. The difference in adverse events in the 2 groups was mostly driven by moderate weight loss for women on the CTART arm.

Original language	English (US)
Pages (from-to)	450-454
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	86
Issue number	4
DOIs	https://doi.org/10.1097/QAI.0000000000002586
State	Published - Apr 1 2021

Keywords

AIDS
ART
HIV
adverse events
breastfeeding
mothers

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0000000000002586

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Brummel, S. S., Taha, T. E., Angelidou, K., Saidi, F., Atuhaire, P., Dula, D., Moodley, D., Matubu, A., Chareka, G., Nevrekar, N., Vhembo, T., Fairlie, L., Theron, G., Mlay, P., George, K., Basar, M., Chakhtoura, N., Browning, R., Fowler, M. G., & Currier, J. S. (2021). Brief Report: Impact of ART on Maternal Health After Cessation of Breastfeeding. Journal of Acquired Immune Deficiency Syndromes, 86(4), 450-454. https://doi.org/10.1097/QAI.0000000000002586

Brummel, SS, Taha, TE, Angelidou, K, Saidi, F, Atuhaire, P, Dula, D, Moodley, D, Matubu, A, Chareka, G, Nevrekar, N, Vhembo, T, Fairlie, L, Theron, G, Mlay, P, George, K, Basar, M, Chakhtoura, N, Browning, R, Fowler, MG & Currier, JS 2021, 'Brief Report: Impact of ART on Maternal Health After Cessation of Breastfeeding', Journal of Acquired Immune Deficiency Syndromes, vol. 86, no. 4, pp. 450-454. https://doi.org/10.1097/QAI.0000000000002586

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abstract = "Abstract:IMPAACT PROMISE 1077BF/FF was a sequentially randomized study of pregnant and postpartum women living with HIV to investigate the efficacy and safety of antiretroviral therapy (ART). This Maternal Health Component investigated efficacy for the risk of developing AIDS or death; and safety among women randomized to continue ART (CTART: N = 289) or discontinue ART (N = 268) after cessation of breastfeeding or after confirmation of infant infection. No AIDS-defining illnesses were reported during follow-up in either arm. Adverse events of grade 3 or higher were more frequent in the CTART arm [hazard ratio = 1.78, 95% confidence interval: (1.05 to 3.02), P-value = 0.03]. The difference in adverse events in the 2 groups was mostly driven by moderate weight loss for women on the CTART arm.",

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AU - Vhembo, Tichaona

AU - Fairlie, Lee

AU - Theron, Gerhard

AU - Mlay, Pendo

AU - George, Kathleen

AU - Basar, Michael

AU - Chakhtoura, Nahida

AU - Browning, Renee

AU - Fowler, Mary Glenn

AU - Currier, Judith S.

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N2 - Abstract:IMPAACT PROMISE 1077BF/FF was a sequentially randomized study of pregnant and postpartum women living with HIV to investigate the efficacy and safety of antiretroviral therapy (ART). This Maternal Health Component investigated efficacy for the risk of developing AIDS or death; and safety among women randomized to continue ART (CTART: N = 289) or discontinue ART (N = 268) after cessation of breastfeeding or after confirmation of infant infection. No AIDS-defining illnesses were reported during follow-up in either arm. Adverse events of grade 3 or higher were more frequent in the CTART arm [hazard ratio = 1.78, 95% confidence interval: (1.05 to 3.02), P-value = 0.03]. The difference in adverse events in the 2 groups was mostly driven by moderate weight loss for women on the CTART arm.

AB - Abstract:IMPAACT PROMISE 1077BF/FF was a sequentially randomized study of pregnant and postpartum women living with HIV to investigate the efficacy and safety of antiretroviral therapy (ART). This Maternal Health Component investigated efficacy for the risk of developing AIDS or death; and safety among women randomized to continue ART (CTART: N = 289) or discontinue ART (N = 268) after cessation of breastfeeding or after confirmation of infant infection. No AIDS-defining illnesses were reported during follow-up in either arm. Adverse events of grade 3 or higher were more frequent in the CTART arm [hazard ratio = 1.78, 95% confidence interval: (1.05 to 3.02), P-value = 0.03]. The difference in adverse events in the 2 groups was mostly driven by moderate weight loss for women on the CTART arm.

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Brief Report: Impact of ART on Maternal Health After Cessation of Breastfeeding

Abstract

Keywords

ASJC Scopus subject areas

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