@article{c579df4423544eba85bafa378c2b8dcf,
title = "Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results from the HIV Prevention Trials Network 052 Trial",
abstract = "Early initiation of antiretroviral treatment (ART) reduces HIV transmission and has health benefits. HIV drug resistance can limit treatment options and compromise use of ART for HIV prevention. We evaluated drug resistance in 85 participants in the HIV Prevention Trials Network 052 trial who started ART at CD4 counts of 350-550 cells per cubic millimeter and failed ART by May 2011; 8.2% had baseline resistance and 35.3% had resistance at ART failure. High baseline viral load and less education were associated with emergence of resistance at ART failure. Resistance at ART failure was observed in 7 of 8 (87.5%) participants who started ART at lower CD4 cell counts.",
keywords = "ART failure, HIV, HPTN 052, early ART, resistance",
author = "Fogel, {Jessica M.} and Hudelson, {Sarah E.} and Ou, {San San} and Stephen Hart and Carole Wallis and Morgado, {Mariza G.} and Shanmugam Saravanan and Srikanth Tripathy and Laura Hovind and Estelle Piwowar-Manning and Devin Sabin and Marybeth McCauley and Theresa Gamble and Zhang, {Xinyi C.} and Eron, {Joseph J.} and Gallant, {Joel E.} and Johnstone Kumwenda and Joseph Makhema and Nagalingeswaran Kumarasamy and Suwat Chariyalertsak and James Hakim and Sharlaa Badal-Faesen and Victor Akelo and Hosseinipour, {Mina C.} and Santos, {Breno R.} and Godbole, {Sheela V.} and Pilotto, {Jose H.} and Beatriz Grinsztejn and Ravindre Panchia and Mayer, {Kenneth H.} and Chen, {Ying Q.} and Cohen, {Myron S.} and Eshleman, {Susan H.}",
note = "Publisher Copyright: {\textcopyright} Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2016",
month = jul,
day = "1",
doi = "10.1097/QAI.0000000000000951",
language = "English (US)",
volume = "72",
pages = "304--309",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}