Brief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results from the HIV Prevention Trials Network 052 Trial

Jessica M. Fogel, Sarah E. Hudelson, San San Ou, Stephen Hart, Carole Wallis, Mariza G. Morgado, Shanmugam Saravanan, Srikanth Tripathy, Laura Hovind, Estelle Piwowar-Manning, Devin Sabin, Marybeth McCauley, Theresa Gamble, Xinyi C. Zhang, Joseph J. Eron, Joel E. Gallant, Johnstone Kumwenda, Joseph Makhema, Nagalingeswaran Kumarasamy, Suwat ChariyalertsakJames Hakim, Sharlaa Badal-Faesen, Victor Akelo, Mina C. Hosseinipour, Breno R. Santos, Sheela V. Godbole, Jose H. Pilotto, Beatriz Grinsztejn, Ravindre Panchia, Kenneth H. Mayer, Ying Q. Chen, Myron S. Cohen, Susan H. Eshleman

Research output: Contribution to journalArticlepeer-review

Abstract

Early initiation of antiretroviral treatment (ART) reduces HIV transmission and has health benefits. HIV drug resistance can limit treatment options and compromise use of ART for HIV prevention. We evaluated drug resistance in 85 participants in the HIV Prevention Trials Network 052 trial who started ART at CD4 counts of 350-550 cells per cubic millimeter and failed ART by May 2011; 8.2% had baseline resistance and 35.3% had resistance at ART failure. High baseline viral load and less education were associated with emergence of resistance at ART failure. Resistance at ART failure was observed in 7 of 8 (87.5%) participants who started ART at lower CD4 cell counts.

Original languageEnglish (US)
Pages (from-to)304-309
Number of pages6
JournalJournal of acquired immune deficiency syndromes
Volume72
Issue number3
DOIs
StatePublished - Jul 1 2016

Keywords

  • ART failure
  • HIV
  • HPTN 052
  • early ART
  • resistance

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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