Brief report: Diet and sex hormones in boys: Findings from the Dietary Intervention Study in children

Joanne F. Dorgan, Robert P. McMahon, Lisa Aronson Friedman, Linda Van Horn, Linda G. Snetselaar, Peter O. Kwiterovich, Ronald M. Lauer, Norman L. Lasser, Victor J. Stevens, Alan Robson, Susan F. Cooper, D. Walt Chandler, Frank A. Franklin, Bruce A. Barton, Blossom H. Patterson, Philip R. Taylor, Arthur Schatzkin

Research output: Contribution to journalArticle

Abstract

Context: Diet reportedly alters serum sex hormone concentrations in adults, but little is known about the influence of diet during puberty on these hormones. Objective: We aimed to determine whether an intervention to lower fat intake during adolescence alters serum sex hormone concentrations and progression through puberty. Design: In 1990-1997, we conducted an ancillary study to the Dietary Intervention Study in Children, a multicenter, randomized, controlled clinical trial to test the safety and efficacy of a cholesterol-lowering dietary intervention in children. Participants: Healthy, prepubertal, 8 to 10 yr olds with elevated low-density lipoprotein cholesterol were randomized to usual care or a behavioral intervention. Of 362 randomized Dietary Intervention Study in Children boys, 354 participated in the ancillary study. Eighty-four percent of boys attended last visits when their median time on trial was 7.1 yr. Intervention: The behavioral intervention continued throughout the duration of the trial and promoted a diet with 28% energy from total fat, less than 8% from saturated fat, 9% or less from polyunsaturated fat, and less than 75 mg cholesterol per 1000 kcal. Outcome Measures: The main outcome measure for boys formulated before study initiation was non-SHBG bound testosterone concentration. Secondary outcomes included serum total testosterone, dihydrotestosterone, androstenedione, estradiol, estrone, SHBG, and Tanner stage. Results: There were no significant treatment group differences in boys' serum hormone levels, SHBG, or Tanner stages at any individual visit or over the course of the trial when evaluated by longitudinal models. Conclusion: Modest reductions in total fat, saturated fat, and possibly energy intake do not alter progression through puberty or serum sex hormone concentrations in adolescent boys.

Original languageEnglish (US)
Pages (from-to)3992-3996
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number10
DOIs
StatePublished - Oct 2006

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Gonadal Steroid Hormones
Nutrition
Fats
Diet
Puberty
Serum
Testosterone
Outcome Assessment (Health Care)
Hormones
Dietary Cholesterol
Androstenedione
Estrone
Dihydrotestosterone
Energy Intake
LDL Cholesterol
Estradiol
Healthy Volunteers
Randomized Controlled Trials
Cholesterol
Safety

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Dorgan, J. F., McMahon, R. P., Friedman, L. A., Van Horn, L., Snetselaar, L. G., Kwiterovich, P. O., ... Schatzkin, A. (2006). Brief report: Diet and sex hormones in boys: Findings from the Dietary Intervention Study in children. Journal of Clinical Endocrinology and Metabolism, 91(10), 3992-3996. https://doi.org/10.1210/jc.2006-0109

Brief report : Diet and sex hormones in boys: Findings from the Dietary Intervention Study in children. / Dorgan, Joanne F.; McMahon, Robert P.; Friedman, Lisa Aronson; Van Horn, Linda; Snetselaar, Linda G.; Kwiterovich, Peter O.; Lauer, Ronald M.; Lasser, Norman L.; Stevens, Victor J.; Robson, Alan; Cooper, Susan F.; Chandler, D. Walt; Franklin, Frank A.; Barton, Bruce A.; Patterson, Blossom H.; Taylor, Philip R.; Schatzkin, Arthur.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 10, 10.2006, p. 3992-3996.

Research output: Contribution to journalArticle

Dorgan, JF, McMahon, RP, Friedman, LA, Van Horn, L, Snetselaar, LG, Kwiterovich, PO, Lauer, RM, Lasser, NL, Stevens, VJ, Robson, A, Cooper, SF, Chandler, DW, Franklin, FA, Barton, BA, Patterson, BH, Taylor, PR & Schatzkin, A 2006, 'Brief report: Diet and sex hormones in boys: Findings from the Dietary Intervention Study in children', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 10, pp. 3992-3996. https://doi.org/10.1210/jc.2006-0109
Dorgan, Joanne F. ; McMahon, Robert P. ; Friedman, Lisa Aronson ; Van Horn, Linda ; Snetselaar, Linda G. ; Kwiterovich, Peter O. ; Lauer, Ronald M. ; Lasser, Norman L. ; Stevens, Victor J. ; Robson, Alan ; Cooper, Susan F. ; Chandler, D. Walt ; Franklin, Frank A. ; Barton, Bruce A. ; Patterson, Blossom H. ; Taylor, Philip R. ; Schatzkin, Arthur. / Brief report : Diet and sex hormones in boys: Findings from the Dietary Intervention Study in children. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 10. pp. 3992-3996.
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AU - Snetselaar, Linda G.

AU - Kwiterovich, Peter O.

AU - Lauer, Ronald M.

AU - Lasser, Norman L.

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AU - Robson, Alan

AU - Cooper, Susan F.

AU - Chandler, D. Walt

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