Brief Report: Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Neil Kumar, Nima Hafezi-Nejad, Ali Guermazi, Arya Haj-Mirzaian, Ida K. Haugen, Frank W. Roemer, Shadpour Demehri

Research output: Contribution to journalArticle

Abstract

Objective: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes are associated with the incidence and progression of radiographic osteoarthritis (OA) of the knee. Methods: We analyzed 8,023 knees (with 8 years of follow-up) from the Osteoarthritis Initiative. Cox regression was performed on Heberden's node presence, total number, location, and symmetry (using 2 symmetry index models) obtained at baseline physical examination as well as self-report of Heberden's node presence for evaluation of association with radiographic knee OA incidence (development of a Kellgren/Lawrence grade of ≥2) and progression (worsening in the medial joint space narrowing score of ≥1). Covariate adjustments relevant to OA outcomes were performed. Results: The presence of Heberden's nodes (in 64% of the subjects) at baseline physical examinations, but not subjective self-report of Heberden's nodes, was associated with radiographic knee OA incidence (hazard ratio [HR] 1.19 and 95% confidence interval [95% CI] 1.001–1.402 [approached statistical significance]). Each additional Heberden's node found on physical examination was associated with knee OA incidence (HR 1.03 [95% CI 1.000–1.054] [approached statistical significance]) and progression (HR 1.04 [95% CI 1.016–1.063]). Knee OA incidence and progression were associated with Heberden's nodes located on the third digit (HR 1.26 [95% CI 1.068–1.487] and 1.18 [95% CI 1.019–1.361], respectively) and first digit (HR 1.186 [95% CI 0.992–1.418] [approached statistical significance] and HR 1.26 [95% CI 1.084–1.453], respectively). Heberden's node symmetry was associated with knee OA incidence (model 1 HR 1.09 [95% CI 0.997–1.185] [approached statistical significance]) and progression (model 2 HR 1.13 [95% CI 1.035–1.234]). Conclusion: The number of Heberden's nodes, their locations, and symmetry were associated with knee OA incidence and progression over 8 years.

Original languageEnglish (US)
Pages (from-to)1234-1239
Number of pages6
JournalArthritis and Rheumatology
Volume70
Issue number8
DOIs
StatePublished - Aug 1 2018

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Knee Osteoarthritis
Osteoarthritis
Confidence Intervals
Incidence
Physical Examination
Proportional Hazards Models
Self Report
Knee
Joints

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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Brief Report : Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative. / Kumar, Neil; Hafezi-Nejad, Nima; Guermazi, Ali; Haj-Mirzaian, Arya; Haugen, Ida K.; Roemer, Frank W.; Demehri, Shadpour.

In: Arthritis and Rheumatology, Vol. 70, No. 8, 01.08.2018, p. 1234-1239.

Research output: Contribution to journalArticle

Kumar, Neil ; Hafezi-Nejad, Nima ; Guermazi, Ali ; Haj-Mirzaian, Arya ; Haugen, Ida K. ; Roemer, Frank W. ; Demehri, Shadpour. / Brief Report : Association of Quantitative and Topographic Assessment of Heberden's Nodes With Knee Osteoarthritis: Data From the Osteoarthritis Initiative. In: Arthritis and Rheumatology. 2018 ; Vol. 70, No. 8. pp. 1234-1239.
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abstract = "Objective: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes are associated with the incidence and progression of radiographic osteoarthritis (OA) of the knee. Methods: We analyzed 8,023 knees (with 8 years of follow-up) from the Osteoarthritis Initiative. Cox regression was performed on Heberden's node presence, total number, location, and symmetry (using 2 symmetry index models) obtained at baseline physical examination as well as self-report of Heberden's node presence for evaluation of association with radiographic knee OA incidence (development of a Kellgren/Lawrence grade of ≥2) and progression (worsening in the medial joint space narrowing score of ≥1). Covariate adjustments relevant to OA outcomes were performed. Results: The presence of Heberden's nodes (in 64{\%} of the subjects) at baseline physical examinations, but not subjective self-report of Heberden's nodes, was associated with radiographic knee OA incidence (hazard ratio [HR] 1.19 and 95{\%} confidence interval [95{\%} CI] 1.001–1.402 [approached statistical significance]). Each additional Heberden's node found on physical examination was associated with knee OA incidence (HR 1.03 [95{\%} CI 1.000–1.054] [approached statistical significance]) and progression (HR 1.04 [95{\%} CI 1.016–1.063]). Knee OA incidence and progression were associated with Heberden's nodes located on the third digit (HR 1.26 [95{\%} CI 1.068–1.487] and 1.18 [95{\%} CI 1.019–1.361], respectively) and first digit (HR 1.186 [95{\%} CI 0.992–1.418] [approached statistical significance] and HR 1.26 [95{\%} CI 1.084–1.453], respectively). Heberden's node symmetry was associated with knee OA incidence (model 1 HR 1.09 [95{\%} CI 0.997–1.185] [approached statistical significance]) and progression (model 2 HR 1.13 [95{\%} CI 1.035–1.234]). Conclusion: The number of Heberden's nodes, their locations, and symmetry were associated with knee OA incidence and progression over 8 years.",
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AU - Hafezi-Nejad, Nima

AU - Guermazi, Ali

AU - Haj-Mirzaian, Arya

AU - Haugen, Ida K.

AU - Roemer, Frank W.

AU - Demehri, Shadpour

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N2 - Objective: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes are associated with the incidence and progression of radiographic osteoarthritis (OA) of the knee. Methods: We analyzed 8,023 knees (with 8 years of follow-up) from the Osteoarthritis Initiative. Cox regression was performed on Heberden's node presence, total number, location, and symmetry (using 2 symmetry index models) obtained at baseline physical examination as well as self-report of Heberden's node presence for evaluation of association with radiographic knee OA incidence (development of a Kellgren/Lawrence grade of ≥2) and progression (worsening in the medial joint space narrowing score of ≥1). Covariate adjustments relevant to OA outcomes were performed. Results: The presence of Heberden's nodes (in 64% of the subjects) at baseline physical examinations, but not subjective self-report of Heberden's nodes, was associated with radiographic knee OA incidence (hazard ratio [HR] 1.19 and 95% confidence interval [95% CI] 1.001–1.402 [approached statistical significance]). Each additional Heberden's node found on physical examination was associated with knee OA incidence (HR 1.03 [95% CI 1.000–1.054] [approached statistical significance]) and progression (HR 1.04 [95% CI 1.016–1.063]). Knee OA incidence and progression were associated with Heberden's nodes located on the third digit (HR 1.26 [95% CI 1.068–1.487] and 1.18 [95% CI 1.019–1.361], respectively) and first digit (HR 1.186 [95% CI 0.992–1.418] [approached statistical significance] and HR 1.26 [95% CI 1.084–1.453], respectively). Heberden's node symmetry was associated with knee OA incidence (model 1 HR 1.09 [95% CI 0.997–1.185] [approached statistical significance]) and progression (model 2 HR 1.13 [95% CI 1.035–1.234]). Conclusion: The number of Heberden's nodes, their locations, and symmetry were associated with knee OA incidence and progression over 8 years.

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