Brief report: Antisynthetase syndrome-associated myocarditis

Research output: Contribution to journalArticle

Abstract

Background The antisynthetase (AS) syndrome is characterized by autoimmune myopathy, interstitial lung disease, cutaneous involvement, arthritis, fever, and antibody specificity. We describe 2 patients with AS syndrome who also developed myocarditis, depressed biventricular function, and congestive heart failure.

Methods and Results Both patients were diagnosed with AS syndrome based on clinical manifestations, detection of serum AS antibodies, and myositis confirmation with the use of skeletal muscle magnetic resonance imaging and skeletal muscle biopsy. In addition, myocarditis resulting in heart failure was confirmed with the use of cardiac magnetic resonance imaging and from endomyocardial biopsy findings. After treatment for presumed AS syndrome-associated myocarditis, one patient recovered and the other patient died.

Conclusions AS syndrome is a rare entity with morbidity and mortality typically attributed to myositis and lung involvement. This is the first report of AS syndrome-associated myocarditis leading to congestive heart failure in 2 patients. Given the potentially fatal consequences, myocarditis should be considered in patients with AS syndrome presenting with heart failure.

Original languageEnglish (US)
Pages (from-to)939-945
Number of pages7
JournalJournal of Cardiac Failure
Volume20
Issue number12
DOIs
StatePublished - Dec 1 2014

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Myocarditis
Heart Failure
Myositis
Skeletal Muscle
Magnetic Resonance Imaging
Biopsy
Antibody Specificity
Interstitial Lung Diseases
Muscular Diseases
Antisynthetase syndrome
Arthritis
Fever
Morbidity
Lung
Skin
Mortality
Antibodies
Serum

Keywords

  • Antisynthetase syndrome
  • heart failure
  • myocarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Brief report: Antisynthetase syndrome-associated myocarditis",
abstract = "Background The antisynthetase (AS) syndrome is characterized by autoimmune myopathy, interstitial lung disease, cutaneous involvement, arthritis, fever, and antibody specificity. We describe 2 patients with AS syndrome who also developed myocarditis, depressed biventricular function, and congestive heart failure.Methods and Results Both patients were diagnosed with AS syndrome based on clinical manifestations, detection of serum AS antibodies, and myositis confirmation with the use of skeletal muscle magnetic resonance imaging and skeletal muscle biopsy. In addition, myocarditis resulting in heart failure was confirmed with the use of cardiac magnetic resonance imaging and from endomyocardial biopsy findings. After treatment for presumed AS syndrome-associated myocarditis, one patient recovered and the other patient died.Conclusions AS syndrome is a rare entity with morbidity and mortality typically attributed to myositis and lung involvement. This is the first report of AS syndrome-associated myocarditis leading to congestive heart failure in 2 patients. Given the potentially fatal consequences, myocarditis should be considered in patients with AS syndrome presenting with heart failure.",
keywords = "Antisynthetase syndrome, heart failure, myocarditis",
author = "Kavita Sharma and Ana-Maria Orbai and Dipan Desai and Oscar Cingolani and Halushka, {Marc K} and Lisa Christopher-Stine and Mammen, {Andrew L.} and Wu, {Katherine Chih-Ching} and Sammy Zakaria",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.cardfail.2014.07.012",
language = "English (US)",
volume = "20",
pages = "939--945",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
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}

TY - JOUR

T1 - Brief report

T2 - Antisynthetase syndrome-associated myocarditis

AU - Sharma, Kavita

AU - Orbai, Ana-Maria

AU - Desai, Dipan

AU - Cingolani, Oscar

AU - Halushka, Marc K

AU - Christopher-Stine, Lisa

AU - Mammen, Andrew L.

AU - Wu, Katherine Chih-Ching

AU - Zakaria, Sammy

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background The antisynthetase (AS) syndrome is characterized by autoimmune myopathy, interstitial lung disease, cutaneous involvement, arthritis, fever, and antibody specificity. We describe 2 patients with AS syndrome who also developed myocarditis, depressed biventricular function, and congestive heart failure.Methods and Results Both patients were diagnosed with AS syndrome based on clinical manifestations, detection of serum AS antibodies, and myositis confirmation with the use of skeletal muscle magnetic resonance imaging and skeletal muscle biopsy. In addition, myocarditis resulting in heart failure was confirmed with the use of cardiac magnetic resonance imaging and from endomyocardial biopsy findings. After treatment for presumed AS syndrome-associated myocarditis, one patient recovered and the other patient died.Conclusions AS syndrome is a rare entity with morbidity and mortality typically attributed to myositis and lung involvement. This is the first report of AS syndrome-associated myocarditis leading to congestive heart failure in 2 patients. Given the potentially fatal consequences, myocarditis should be considered in patients with AS syndrome presenting with heart failure.

AB - Background The antisynthetase (AS) syndrome is characterized by autoimmune myopathy, interstitial lung disease, cutaneous involvement, arthritis, fever, and antibody specificity. We describe 2 patients with AS syndrome who also developed myocarditis, depressed biventricular function, and congestive heart failure.Methods and Results Both patients were diagnosed with AS syndrome based on clinical manifestations, detection of serum AS antibodies, and myositis confirmation with the use of skeletal muscle magnetic resonance imaging and skeletal muscle biopsy. In addition, myocarditis resulting in heart failure was confirmed with the use of cardiac magnetic resonance imaging and from endomyocardial biopsy findings. After treatment for presumed AS syndrome-associated myocarditis, one patient recovered and the other patient died.Conclusions AS syndrome is a rare entity with morbidity and mortality typically attributed to myositis and lung involvement. This is the first report of AS syndrome-associated myocarditis leading to congestive heart failure in 2 patients. Given the potentially fatal consequences, myocarditis should be considered in patients with AS syndrome presenting with heart failure.

KW - Antisynthetase syndrome

KW - heart failure

KW - myocarditis

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