Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids

Solange P. Brown, Stephan D. Brenowitz, Wade G. Regehr

Research output: Contribution to journalArticlepeer-review

Abstract

Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked endocannabinoid release, which strongly inhibited parallel fiber-to-Purkinje cell synapses in rat cerebellar slices. This retrograde inhibition was triggered by activation of either postsynaptic metabotropic or ionotropic glutamate receptors and was restricted to synapses activated with high-frequency bursts. Thus, endocannabinoids allow neurons to inhibit specific synaptic inputs in response to a burst, thereby dynamically fine-tuning the properties of synaptic integration.

Original languageEnglish (US)
Pages (from-to)1048-1057
Number of pages10
JournalNature neuroscience
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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