Brief communication: Urinary excretion by cancer patients of the nucleosides n2, n2-dimethylguanosine, 1-methylinosine, and pseudouridine

T. Phillip Waalkes, Stanley R. Dinsmore, John E. Mrochek

Research output: Contribution to journalArticlepeer-review


Through high-pressure, high-resolution, liquid ion exchange chromatography, in association with such analytic tools as gas chromatography, gas chromatography-mass spectrometry, and high- and low- resolution mass spectrometry, the nucleosides N2, N2-dimethylguanosine, 1-methylinosine, and pseudouridine, were identified and quantitatively determined in the urine of normal c ontrol subjects and patients with cancer. These nucleosides were derived primarily from transfer RNA, and their excretion reflected the turnover of that macromolecule. In this preliminary study of several types of malignancies, we noted increased excretion of these compounds in at least half of the patients, as compared with normal controls.—J Natl Cancer Inst 51: 271-274, 1973.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalJournal of the National Cancer Institute
Issue number1
StatePublished - Jul 1973

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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