@article{81a5a5b6563e40b9a230987b6f1ff5a4,
title = "Brief communication: The gardner syndrome: A family study in cell culture",
abstract = "The occurrence of tetraploidy was studied in skin cultures containing both epithelioid and fibroblastic cells derived from 137 members (28 clinically affected, 50 normals at risk and 59 normals not at risk) of 6 families with the Gardner syndrome (3 classical, 3 variant). The cultures from all 28 affected members showed increased tetraploidy. Among the 50 normal members at risk for inheriting the Gardner gene, the cultures from 19 had increased tetraploidy and those from 31 did not. Cultures from 56 of the 59 family members not at risk did not show increased tetraploidy. Although the families were divided into subgroups (classical and variant) on clinical phenotypes, no such subdivision could be made on the basis of increased tetraploidy in skin cultures.",
author = "Danes, {B. Shannon} and Krush, {Anne J.}",
note = "Funding Information: 1 Received April 20, 1976; accepted August 25, 1976. 2 Supported in part by Public Health Service grant CA15973 from the National Large Bowel Cancer Project, Division of Cancer Research, National Cancer Institute, and by funds from The National Foundation-March of Dimes, the Danes Medical Research Fund, Cornell University Medical College, and the Zemurray Foundation. 3 Laboratory for Cell Genetics, Department of Medicine, Cornell University Medical College, New York, N. Y. 10021. 4 The Moore Clinic, Department of Medicine, The Johns Hopkins Hospital, Baltimore, Md. 21205. 5 Drs. E. J. B u rbige, F. D. Milligan, and their clinical colleagues did the clinical evaluations for all six families studied. Mrs. Anne J. Krush obtained the family data, and M.F.D. and Mrs. Sirarpy Torossian prepared the two pedigrees included in this paper.",
year = "1977",
month = mar,
doi = "10.1093/jnci/58.3.771",
language = "English (US)",
volume = "58",
pages = "771--775",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "3",
}